CONFINED AND CONDITIONALLY ACTIVATED BINDING PROTEIN

Title:

CONFINED AND CONDITIONALLY ACTIVATED BINDING PROTEIN

Document Type and Number:

Japanese Patent JP2023093632

Kind Code:

A

Abstract:

To provide a protein for treating cancer which is selectively activated in the presence of tumor protease.SOLUTION: Protein includes a first antigen binding domain binding a human tumor target antigen, a first domain linker, a confined Fv domain including a first variable heavy domain, a confined non-cleavable linker and a first variable light domain, a second domain linker, a second antigen binding domain, a cleavable linker, and a confined pseudo Fv domain including a first pseudo light variable domain, a non-cleavable linker and a first pseudo heavy variable domain, and includes a third domain linker, and a third antigen binding domain binding human serum albumin.SELECTED DRAWING: None

Inventors:

CHAD MAY
ROBERT B DUBRIDGE
MAIA VINOGRADOVA
ANAND PANCHAL

Application Number:

JP2023069230A

Publication Date:

July 04, 2023

Filing Date:

April 20, 2023

Export Citation:

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Assignee:

TAKEDA PHARMACEUTICAL

International Classes:

C12N15/62; A61K39/395; A61K47/68; A61P35/00; A61P43/00; C07K16/28; C07K16/46; C12N1/15; C12N1/19; C12N1/21; C12N5/10; C12N15/13; C12N15/63; C12P21/08

Attorney, Agent or Firm:

Norito Yamao
Michiko Matsutani
Yoko Sakurai

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