Title:
共役化された低分子
Document Type and Number:
Japanese Patent JP2007521338
Kind Code:
A
Abstract:
Provided herein are linker compounds and conjugates that include the linker compounds. In one embodiment, the linker compounds comprise 2 or 3 residues of 6-aminohexanoic acid and optionally 7-10 residues of polyethyleneglycol (PEG). The linker compounds are useful in forming conjugates with one or more components useful in biopharmaceutical or bioanalytical applications. In particular, the biopharmaceutically useful compounds are kinase inhibitors. The conjugates described herein have utility in a variety of diagnostic, separation, and therapeutic applications.
Inventors:
Grozfeld Robert M.
Milan Buzdrafko Kei.
Patel Hitesh Kay.
Ryan Dizzy.
Meter Shamalei.
Lockhart David Jay.
Milan Buzdrafko Kei.
Patel Hitesh Kay.
Ryan Dizzy.
Meter Shamalei.
Lockhart David Jay.
Application Number:
JP2006549423A
Publication Date:
August 02, 2007
Filing Date:
January 07, 2005
Export Citation:
Assignee:
Ambit Bioscience Corp.
International Classes:
C07C247/04; A61K39/385; A61K47/48; A61K49/00; A61K51/00; A61P1/04; A61P3/14; A61P17/04; A61P31/04; A61P43/00; C07C247/08; C07D295/10; C07D295/24; C07D401/04; C07D403/12; C07D417/12; C07D417/14; C07D495/04; C07D519/00; C07H17/08; C07H19/04; C07H19/20; G01N33/53; G01N33/533; G01N33/535; G01N33/543; A61K31/4188; A61K31/437; A61K31/4439; A61K31/454; A61K31/4725; A61K31/496; A61K31/502; A61K31/517; A61K31/519; A61K31/52; A61K31/5377; A61K31/551; A61K31/553; A61K31/7048; A61K31/7076; A61K38/00
Domestic Patent References:
| JP2002538478A | 2002-11-12 | |||
| JP2001508657A | 2001-07-03 | |||
| JP2001503407A | 2001-03-13 | |||
| JP2002501535A | 2002-01-15 | |||
| JPS60226888A | 1985-11-12 |
Foreign References:
| WO2004063195A1 | 2004-07-29 | |||
| EP0432017A1 | 1991-06-12 | |||
| EP0767383A1 | 1997-04-09 | |||
| WO2002090319A1 | 2002-11-14 | |||
| WO2003097609A1 | 2003-11-27 |
Attorney, Agent or Firm:
Hatsushi Shimizu
Koichi Niimi
Koichi Niimi