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Title:
CONJUGATES AS THERAPIES FOR CANCERS AND PROSTATE DISEASES
Document Type and Number:
Japanese Patent JP2007204493
Kind Code:
A
Abstract:

To develop the new treatment of prostatic cancer, maintaining the potential of chemotherapy without being supplied to various side effects and the disadvantages of the present therapies.

This therapeutic composition containing a peptide substrate covalently bound to a cell proliferation inhibitor or a cytocidal agent, wherein an enzyme catalyzes the cleavage of the peptide substrate from the cell proliferation inhibitor or the cytocidal agent. The cell proliferation inhibitor or the cytocidal agent may be a polyamine. The analogue of the polyamine may be bound to the peptide at the carboxy terminal of the peptide by the amide bond of the polyamine to a primary amine or secondary amine.

COPYRIGHT: (C)2007,JPO&INPIT


Inventors:
FRYDMAN BENJAMIN
MARTON LAURENCE J
Application Number:
JP2007117798A
Publication Date:
August 16, 2007
Filing Date:
April 26, 2007
Export Citation:
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Assignee:
CELLGATE INC
International Classes:
A61K38/00; A61K31/122; A61K31/133; A61K31/16; A61K31/165; A61K31/22; A61K31/24; A61K31/277; A61K31/343; A61K31/353; A61K31/401; A61K31/409; A61K31/4184; A61K31/473; A61K31/496; A61K31/5377; A61K31/6615; A61K31/7034; A61K38/10; A61K45/00; A61K47/48; A61P13/08; A61P15/00; A61P35/00; A61P43/00; C07C45/46; C07C67/343; C07D207/34; C07D219/10; C07D235/18; C07D295/185; C07D307/79; C07D307/92; C07D311/92; C07D317/70; C07D487/22; C07D493/04; C07K5/103; C07K7/06; C07K5/10
Foreign References:
WO1998017624A11998-04-30
WO1999003823A21999-01-28
Attorney, Agent or Firm:
Hidesaku Yamamoto
Takaaki Yasumura
Natsuki Morishita