To provide a connection structure of an integrated panel and a fluid device capable of maintaining satisfactory sealing property without retightening it and improving the assembly workability.

Annular projections 11, 21 are formed in first and second fluid supply/discharge openings 1A, 2A so as to communicate between the integrated panel 1 and a valve 2 with single circular tube-like fluid passages 3, 7 maintained in a sealed state by employing annular gaskets G. The gasket G is made of a fluorocarbon resin, provided with a pair of annular grooves 51, 51 formed in an outside-diameter side of a fluid route W so as to be fitted to each of the annular projections 11, 21, and equipped with a maintaining means I for maintaining a joining state in which a fitting seal section is formed by pulling the integrated panel 1 and the valve 2 together and fitting the annular projections 11, 21 of the first and second supply/discharge openings 1A, 2A and the annular grooves 51 of the gasket G to each other.