Title:
CONSERVED MOTIF OF HEPATITIS C VIRUS E2/NS1 REGION
Document Type and Number:
Japanese Patent JP2005325126
Kind Code:
A
Abstract:
To provide an antibody, a peptide, a method and a composition for carrying out passive immunization of individual for treatment of infection of hepatitis C virus (HCV).
The hypervariable region (E2HV) of the putative hepatitis C virus (HCV) glycoprotein E2/NS1, between about amino acid 384 to about amino acid 414, is a rapidly evolving region of HCV, and is likely to be under positive immune selection. A newly discovered motif within this hypervariable region is immunogenic and conserved with respect to the character of the amino acids. In many isolates, this motif falls between amino acids 401 to 406 or 407. The discovery of this motif allows for additional materials and methods to treat and diagnose HCV.
Inventors:
WEINER AMY J
HOUGHTON MICHAEL
HOUGHTON MICHAEL
Application Number:
JP2005152406A
Publication Date:
November 24, 2005
Filing Date:
May 25, 2005
Export Citation:
Assignee:
CHIRON CORP
International Classes:
A61K39/395; A61K39/00; A61K39/29; A61P1/16; A61P31/12; A61P31/14; C07K7/06; C07K14/18; C07K16/10; C12N15/02; C12N15/09; C12P21/02; C12P21/08; C12Q1/70; G01N33/576; A61K38/00; (IPC1-7): C07K14/18; A61K39/29; A61P1/16; A61P31/14; G01N33/576
Attorney, Agent or Firm:
Hidesaku Yamamoto
Takaaki Yasumura
Natsuki Morishita
Takaaki Yasumura
Natsuki Morishita