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Title:
構成的脱感作Gタンパク質共役受容体
Document Type and Number:
Japanese Patent JP2004524834
Kind Code:
A
Abstract:
The present invention relates to modified G-protein coupled receptors (GPCRs). The modified GPCRs of the present invention include GPCRs that have been modified to have altered DRY motifs such that the modified GPCRs are constitutively desensitized. As such, the modified GPCRs of the present invention preferably localize to endocytic vesicles or endosomes in an agonist-independent manner. The invention also relates to methods of screening compounds and sample solutions for GPCR activity using the modified GPCRs.

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Inventors:
Barrack, Larry S
Oakley, robert h
Caron, mark gee
La Paul, Stephen A.
Wilbanks, allison
Application Number:
JP2002559554A
Publication Date:
August 19, 2004
Filing Date:
January 23, 2002
Export Citation:
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Assignee:
GENERAL ELECTRIC COMPANY
International Classes:
A61K31/41; A61K31/417; A61K31/437; A61K31/64; A61K45/00; A61P1/00; A61P1/04; A61P3/04; A61P3/10; A61P9/00; A61P9/04; A61P9/06; A61P9/10; A61P9/12; A61P11/06; A61P11/08; A61P13/12; A61P25/00; A61P25/16; A61P25/22; A61P25/24; A61P25/28; A61P27/06; A61P27/16; A61P29/00; A61P31/00; A61P35/00; A61P37/08; A61P43/00; C07D233/24; C07D471/04; C07K14/705; C07K14/72; C07K16/28; C07K19/00; C12N1/15; C12N1/19; C12N1/21; C12N5/10; C12N15/09; C12N15/12; C12P21/08; C12Q1/02; C12Q1/68; G01N33/15; A01K67/027; G01N33/50; G01N33/53; G01N33/577; A61K38/00; (IPC1-7): C12N15/09; A01K67/027; A61K31/417; A61K31/437; A61K45/00; A61P1/00; A61P1/04; A61P3/04; A61P3/10; A61P9/00; A61P9/04; A61P9/06; A61P9/10; A61P9/12; A61P11/06; A61P11/08; A61P13/12; A61P25/00; A61P25/16; A61P25/22; A61P25/24; A61P25/28; A61P27/06; A61P27/16; A61P29/00; A61P31/00; A61P35/00; A61P37/08; A61P43/00; C07D233/24; C07D471/04; C07K14/705; C07K16/28; C07K19/00; C12N1/15; C12N1/19; C12N1/21; C12N5/10; C12Q1/02; C12Q1/68; G01N33/15; G01N33/50; G01N33/53; G01N33/577
Attorney, Agent or Firm:
Shoichi Okuyama
Arihara Koichi
Matsushima Tetsuo



 
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