CONSTRUCT HAVING SIRP-ALPHA DOMAIN OR VARIANT THEREOF

Title:

CONSTRUCT HAVING SIRP-ALPHA DOMAIN OR VARIANT THEREOF

Document Type and Number:

Japanese Patent JP2023061969

Kind Code:

A

Abstract:

To provide signal-regulatory protein a (SIRP-α) polypeptides and constructs that are useful, e.g., to target a cell (e.g., a cancer cell or a cell of the immune system), to increase phagocytosis of the target cell, to eliminate immune cells such as regulatory T-cells, to kill cancer cells, to treat a disease (e.g., cancer) in a subject, or any combinations thereof.SOLUTION: An SIRP-α construct includes a high affinity SIRP-α D1 domain or a variant thereof that binds CD47 with higher affinity than a wild-type SIRP-α.SELECTED DRAWING: Figure 3

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Inventors:

Pons, Jaume
deming, laura
goodman, collie
Sim, Ban Janet
Cowder, Stephen Elliott
One, Hong
Kuo, Tracy Chia-Chen

Application Number:

JP2023010460A

Publication Date:

May 02, 2023

Filing Date:

January 26, 2023

Export Citation:

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Assignee:

ALX Oncology Incorporated

International Classes:

C07K14/47; A61K38/17; A61K39/395; A61P29/00; A61P35/00; A61P35/02; A61P37/04; A61P43/00; C07K19/00

Attorney, Agent or Firm:

Sonoda & Kobayashi Patent Attorneys Corporation

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