Title:
ペネム系化合物の連続後処理方法及び装置
Document Type and Number:
Japanese Patent JP7430256
Kind Code:
B2
Abstract:
Provided are a continuous post-treatment method and device for a penem compound. The method includes the following steps: S1, performing continuous extraction on a reaction crude product of a penem compound, to obtain an extraction heavy phase and an extraction light phase; S2, performing continuous solid-liquid separation on the extraction heavy phase, to obtain a liquid phase separation product; S3, performing continuous pH adjustment on the liquid phase separation product until a pH value thereof is 6.1-6.3, to obtain pH-adjusted solution; and S4, performing continuous crystallization treatment on the pH-adjusted solution by using a first crystallization solvent, to obtain a penem compound product. The use of the method for the post-treatment of the reaction crude product of the penem compound has the advantages of high treatment speed and high efficiency, and stable material properties and a low deterioration rate during the treatment, and has better control over the yield and purity of a target product.
Inventors:
horn, hao
horn, rear
Tao, Jien
Guo, Jinhai
Juyoung, Sien
Jaan, Yen
horn, rear
Tao, Jien
Guo, Jinhai
Juyoung, Sien
Jaan, Yen
Application Number:
JP2022522846A
Publication Date:
February 09, 2024
Filing Date:
October 15, 2019
Export Citation:
Assignee:
Asimchem Laboratories (Tahnjin) Company Limited
International Classes:
C07D477/02; B01D9/02; B01D11/04; C07D477/20
Domestic Patent References:
| JP2012525339A |
Foreign References:
| WO2007111328A1 | ||||
| CN102260264A | ||||
| CN102633801A | ||||
| CN108837558A | ||||
| CN109776646A |
Attorney, Agent or Firm:
Tadashige Ito
Tadahiko Ito
Osamu Miyazaki
Tadahiko Ito
Osamu Miyazaki
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