CONTINUOUSLY RELEASING GEMFIBROZYL COMPOSITION

Title:

CONTINUOUSLY RELEASING GEMFIBROZYL COMPOSITION

Document Type and Number:

Japanese Patent JPH02235810

Kind Code:

A

Abstract:

PURPOSE: To obtain the subject composition capable of providing both of instant release and enteric release by compressing and tableting a mixture of first granules comprising finely divided particles of gemfibrozil with second granules obtained by subjecting the first granules to regranulation, etc., with an acid- disintegratable composition. CONSTITUTION: This composition is obtained by compressing and tableting a mixture of first granules comprising finely divided particles of gemfibrozil [=5-(2,5-dimethylphenoxy)-2,2dimethylpentanoic acid] regranulated with at least one acid-disintgegratable binder such as fine crystalline cellulose or polyvinylpyrrolidone and widely used as antihyperlipoproteinemia with second granules comprising the first granules regranulated or coated with an alkali- disintegratable composition comprising at least one polymer which is substantially alkali-soluble and substantially acid-insoluble, e.g. cellulose phthalates or partially esterified poly(meth)acrylic acid.

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Inventors:

AIZAKU GEIBAA-SERASHII
UUMA IIYAA
MAADEI BAKURU FUAUJI

Application Number:

JP2055390A

Publication Date:

September 18, 1990

Filing Date:

February 01, 1990

Export Citation:

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Assignee:

WARNER LAMBERT CO

International Classes:

A61K9/00; A61K9/20; A61K9/22; A61K9/26; A61K31/19; A61P3/06; (IPC1-7): A61K9/00; A61K9/26; A61K31/19

Attorney, Agent or Firm:

Chika Takagi (2 outside)

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