Title:
CONTRAST COMPOSITION FOR MRI DIAGNOSIS
Document Type and Number:
Japanese Patent JP3729514
Kind Code:
B2
Abstract:
PURPOSE: To provide a contract composition capable of being applied to the lower part tissues of a living body and used for MRI (nuclear magnetic resonance image) diagnose.
CONSTITUTION: A contrast composition is characterized by containing free divalent magnesium cations large in an effect for shortening a spin-lattice relaxation time T1 as a paramagnetic substance for imaging with MRI as the main ingredient of the contrast composition. The concentration of the magnesium cations is optimized within a range of 5-50μm/nl so that the contrast agent is brightly expressed in a T1-emphasized image and that the contrast agent is darkly expressed in a T2-emphasized image (T2 is a spin-spin relaxation time). A MRI diagnose highly safe for living bodies can be performed in a fine dose of the manganese ions by directly administering the contrast composition into a living body lower part tissue such as a large intestine, a bladder or an uterus. Since the original brightness of the T2-emphasized image is not interfered within the concentration range, the diagnose of a tumor lesion is not inhibited.
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Inventors:
Hideo Hasegawa
Yu Kuwata
Ryo Yamamoto
Fujita Osamu
Kumiko Hiraishi
Narabayashi Isamu
Yu Kuwata
Ryo Yamamoto
Fujita Osamu
Kumiko Hiraishi
Narabayashi Isamu
Application Number:
JP17048793A
Publication Date:
December 21, 2005
Filing Date:
July 09, 1993
Export Citation:
Assignee:
Meiji Dairy Co., Ltd.
International Classes:
A61K49/00; (IPC1-7): A61K49/00
Domestic Patent References:
| JP2911674B2 | ||||
| JP3490468B2 | ||||
| JP1259850A |
Foreign References:
| WO1992010213A1 |
Other References:
Cory DA et al.,Magn Reson Imaging.,1987年,5(1),65-70
Attorney, Agent or Firm:
Akira Koike
Eiichi Tamura
Seiji Iga
Eiichi Tamura
Seiji Iga