Title:
ALK5調整剤を用いた眼内圧のコントロール
Document Type and Number:
Japanese Patent JP2009519977
Kind Code:
A
Abstract:
An ophthalmic pharmaceutical composition useful in the treatment of glaucoma and control of intraocular pressure comprising an effective amount of a selective modulator of ALK5 receptor activity is disclosed. Also disclosed is a method of treating glaucoma and controlling intraocular pressure comprising applying a therapeutically effective amount of a pharmaceutical composition comprising a selective modulator of ALK5 receptor activity to an affected eye of a patient.
Inventors:
Freenoah, Debra El.
Bread, iok-ho
Shepherd, Alan Earl.
Helberg, Mark Earl.
Clark, Abbott F.
Crimco, Peter G.
Bread, iok-ho
Shepherd, Alan Earl.
Helberg, Mark Earl.
Clark, Abbott F.
Crimco, Peter G.
Application Number:
JP2008545986A
Publication Date:
May 21, 2009
Filing Date:
December 15, 2006
Export Citation:
Assignee:
Archon, Inc.
International Classes:
A61K45/00; A61K31/4439; A61K31/4709; A61K31/498; A61K31/506; A61K31/519; A61K31/5377; A61P27/06; G01N33/15; G01N33/50; C07D401/12; C07D401/14; C07D405/14; C07D413/04; C07D417/12; C07D471/04; C07D487/04
Domestic Patent References:
| JP2005060360A | 2005-03-10 | |||
| JP2005060360A | 2005-03-10 |
Foreign References:
| US20040152738A1 | 2004-08-05 | |||
| WO2005105069A1 | 2005-11-10 | |||
| US20040152738A1 | 2004-08-05 | |||
| WO2005105069A1 | 2005-11-10 |
Other References:
JPN6011064070; メルクマニュアル日本語版 第１７版, 19991210, ｐｐ．７３１-７３５, 日経ＢＰ社
JPN6011064070; メルクマニュアル日本語版 第１７版, 19991210, ｐｐ．７３１-７３５, 日経ＢＰ社
JPN6011064071; Ｃａｌｌａｈａｎ ＪＦ ｅｔ ａｌ．: 'Ｉｄｅｎｔｉｆｉｃａｔｉｏｎ ｏｆ ｎｏｖｅｌ ｉｎｈｉｂｉｔｏｒｓ ｏｆ ｔｈｅ ｔｒａｎｓｆｏｒｍｉｎｇ ｇｒｏｗｔｈ ｆａｃｔｏｒ ｂｅｔａ１ （ＴＧＦ-ｂｅｔａ１） ｔｙｐｅ １ ｒｅｃｅｐｔ' Ｊ Ｍｅｄ Ｃｈｅｍ． Ｖｏｌ．４５ ｎｏ．５, 20020228, ｐｐ．９９９-１００１
JPN6011064072; Ｓａｗｙｅｒ ＪＳ ｅｔ ａｌ．: 'Ｓｙｎｔｈｅｓｉｓ ａｎｄ ａｃｔｉｖｉｔｙ ｏｆ ｎｅｗ ａｒｙｌ- ａｎｄ ｈｅｔｅｒｏａｒｙｌ-ｓｕｂｓｔｉｔｕｔｅｄ ｐｙｒａｚｏｌｅ ｉｎｈｉｂｉｔｏｒｓ ｏｆ ｔｈｅ ｔｒａｎｓｆｏｒｍｉ' Ｊ Ｍｅｄ Ｃｈｅｍ． Ｖｏｌ．４６ ｎｏ．１９, 20030911, ｐｐ．３９５３-３９５６
JPN6011064070; メルクマニュアル日本語版 第１７版, 19991210, ｐｐ．７３１-７３５, 日経ＢＰ社
JPN6011064071; Ｃａｌｌａｈａｎ ＪＦ ｅｔ ａｌ．: 'Ｉｄｅｎｔｉｆｉｃａｔｉｏｎ ｏｆ ｎｏｖｅｌ ｉｎｈｉｂｉｔｏｒｓ ｏｆ ｔｈｅ ｔｒａｎｓｆｏｒｍｉｎｇ ｇｒｏｗｔｈ ｆａｃｔｏｒ ｂｅｔａ１ （ＴＧＦ-ｂｅｔａ１） ｔｙｐｅ １ ｒｅｃｅｐｔ' Ｊ Ｍｅｄ Ｃｈｅｍ． Ｖｏｌ．４５ ｎｏ．５, 20020228, ｐｐ．９９９-１００１
JPN6011064072; Ｓａｗｙｅｒ ＪＳ ｅｔ ａｌ．: 'Ｓｙｎｔｈｅｓｉｓ ａｎｄ ａｃｔｉｖｉｔｙ ｏｆ ｎｅｗ ａｒｙｌ- ａｎｄ ｈｅｔｅｒｏａｒｙｌ-ｓｕｂｓｔｉｔｕｔｅｄ ｐｙｒａｚｏｌｅ ｉｎｈｉｂｉｔｏｒｓ ｏｆ ｔｈｅ ｔｒａｎｓｆｏｒｍｉ' Ｊ Ｍｅｄ Ｃｈｅｍ． Ｖｏｌ．４６ ｎｏ．１９, 20030911, ｐｐ．３９５３-３９５６
Attorney, Agent or Firm:
Hidesaku Yamamoto
Takaaki Yasumura
Natsuki Morishita
Takaaki Yasumura
Natsuki Morishita