To obtain controlled release granules capable of easily producing and controlling a releasing speed of ibudilast, dividedly administering to the child and young and being taken by the old and being expected to enhance compliance of patients.
These controlled release granules are produced by heating and melting a mixture of (A) ibudilast (e.g.; 3-isobytylyl-2-isopropylazoro[1,5- a]pyridine, expressed by the formula), (B) a high molecular compound and (C) an oily base material to obtain a uniform solution which is cooled and granulated. As the component B, ethylcellulose, methylcellulose, hydroxypropylcellulose, hydroxypropylmethylcellulose, hydroxypropylmethylcellulose phthalate, hydroxypropylmethylcellulose acetate succinate, cellulose acetate phthalate, cellulose acetate, eudragit L, eudragit S, polyvinyl pyrrolidone, etc., can preferably be used.
WATOU TAKAHIKO
YAMADA AKIYA
OYAMA HISANORI
FUWA NAOYUKI
KYORIN SEIYAKU KK