Title:
CONTROLLED-RELEASE HYDROCODONE FORMULATION
Document Type and Number:
Japanese Patent JP2008231110
Kind Code:
A
Abstract:
To provide a solid controlled-release oral formulation suitable for administration of every 24 hours to a human patient.
The solid controlled-release oral formulation includes, (a) a pharmaceutically acceptable matrix including an analgesically effective amount of hydrocodone or a pharmaceutically acceptable salt thereof and controlled release material or (b) an analgesically effective amount of hydrocodone or a pharmaceutically acceptable salt thereof coated onto a plurality of inert pharmaceutically acceptable beads and overcoated with a controlled-release material, and provides a C24/Cmax ratio of 0.55 to about 0.85 after administration, and provides a therapeutic effect for at least about 24 hours dosing in a human patient.
More Like This:
| WO/1996/001629 | HYDROMORPHONE THERAPY |
| WO/1998/043978 | MORPHINANE DERIVATIVES AND MEDICINAL USE THEREOF |
| WO/2001/058447 | CONTROLLED-RELEASE COMPOSITIONS CONTAINING OPIOID AGONIST AND ANTAGONIST |
Inventors:
BENJAMIN OSHLACK
HUANG HUA-PIN
TONELLI ALFRED P
MASSELINK JOHN
HUANG HUA-PIN
TONELLI ALFRED P
MASSELINK JOHN
Application Number:
JP2008100149A
Publication Date:
October 02, 2008
Filing Date:
April 08, 2008
Export Citation:
Assignee:
EURO CELTIQUE SA
International Classes:
A61K31/485; A61K9/00; C07D489/02; A61K9/20; A61K9/22; A61K9/24; A61K9/26; A61K9/36; A61K9/52; A61K9/54; A61K47/32; A61K47/46; A61P25/04
Domestic Patent References:
| JPH10508608A | 1998-08-25 | |||
| JPH09505602A | 1997-06-03 | |||
| JPH07206679A | 1995-08-08 | |||
| JPH032114A | 1991-01-08 | |||
| JPH09136845A | 1997-05-27 |
Foreign References:
| AU4449399A | 1999-10-14 | |||
| WO1998041194A1 | 1998-09-24 | |||
| WO1999032120A1 | 1999-07-01 | |||
| WO1999044591A1 | 1999-09-10 |
Attorney, Agent or Firm:
Hiroshi Kobayashi
Eiji Katayama
Junko Kobayashi
Norio Omori
Yasuhito Suzuki
Eiji Katayama
Junko Kobayashi
Norio Omori
Yasuhito Suzuki