Title:
分子量マーカーとして用いるための、及び治療用途のための、共重合体1関連ポリペプチド
Document Type and Number:
Japanese Patent JP4903886
Kind Code:
B2
Abstract:
The present invention provides molecular weight markers for accurate determination of the molecular weight of glatiramer acetate and other copolymers. The present invention further provides a plurality of molecular weight markers for determining the molecular weight of glatiramer acetate and other copolymers which display linear relationships between molar ellipticity and molecular weight, and between retention time and the log of the molecular weight. The molecular weight markers also optimally demonstrate biological activity similar to glatiramer acetate or corresponding copolymers and can be used for treating or preventing various immune diseases.
Inventors:
Alexander Gadd
Dora squirrel
Dora squirrel
Application Number:
JP2010142689A
Publication Date:
March 28, 2012
Filing Date:
June 23, 2010
Export Citation:
Assignee:
YEDA RESEARCH AND DEVELOPMENT COMPANY LIMITED
International Classes:
C07K14/00; A61K38/00; G01N30/04; A61K38/16; A61K38/21; A61K39/395; A61K45/00; A61P19/02; A61P25/00; A61P29/00; A61P37/00; A61P37/02; G01N30/88; G01N33/68
Domestic Patent References:
| JP3139279A |
Other References:
TEITELBAUM,ISR. J. MED. SCI.,1997年 4月,V33,P280-284
TEITELBAUM,J. NEUROIMMUNOL.,1996年,V64,P209-217
TEITELBAUM,EUR. J. IMMUNOL.,1971年,V1,P242-248
SELA,BULL. INST. PASTEUR,1990年,V88,P303-314
TEITELBAUM,PROC. NATL. ACAD. SCI. USA,1992年 1月,V89,P137-141
FRIDKIS-HARELI,PROC. NATL. ACAD. SCI. USA,1994年 5月,V91,P4872-4876
TEITELBAUM,J. NEUROIMMUNOL.,1996年,V64,P209-217
TEITELBAUM,EUR. J. IMMUNOL.,1971年,V1,P242-248
SELA,BULL. INST. PASTEUR,1990年,V88,P303-314
TEITELBAUM,PROC. NATL. ACAD. SCI. USA,1992年 1月,V89,P137-141
FRIDKIS-HARELI,PROC. NATL. ACAD. SCI. USA,1994年 5月,V91,P4872-4876
Attorney, Agent or Firm:
Sadao Muramatsu
Toshio Shirane
Toshio Shirane