ＦＸＢ及びＴＧＲ５／ＧＰＢＡＲ１介在性疾患の治療及び／又は予防に使用するためのコラン誘導体 - Bur Pharmaceuticals Sochieta Responsabilita Limitata

Title:

ＦＸＢ及びＴＧＲ５／ＧＰＢＡＲ１介在性疾患の治療及び／又は予防に使用するためのコラン誘導体

Document Type and Number:

Japanese Patent JP6820253

Kind Code:

B2

Abstract:

The present invention relates to compounds having cholane scaffolds of formula (I), said compounds for use in the treatment and/or prevention of FXR and TGR5/GPBAR1 mediated diseases.

Inventors:

Angela Zampella
Stefano Fiorucci

Application Number:

JP2017514960A

Publication Date:

January 27, 2021

Filing Date:

May 28, 2015

Export Citation:

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Assignee:

Bur Pharmaceuticals Sochieta Responsabilita Limitata

International Classes:

C07J9/00; A61K31/575; A61P1/00; A61P1/04; A61P1/16; A61P3/00; A61P3/04; A61P3/06; A61P3/10; A61P5/38; A61P5/50; A61P9/00; A61P9/10; A61P13/12; A61P17/02; A61P19/02; A61P21/00; A61P25/00; A61P29/00; A61P31/00; A61P31/14; A61P31/18; A61P31/20; A61P35/00; A61P37/02; A61P43/00; C07J11/00

Foreign References:

US20080119443
WO2013020108A1
US20110294767
WO2006122977A1
US20110172198

Other References:

Journal of Medicinal Chemistry,2014年 1月,Vol.57,pp.937-954
Journal of Medicinal Chemistry,2014年 9月,Vol.57,pp.8477-8495
Journal of Medicinal Chemistry,2002年,Vol.45, No.17,p.3569-3572
Journal of Lipid Research,2010年,Vol. 51,p.1432-1441
Journal of Lipid Research,2004年,Vol.45,p.132-138
Journal of Medicinal Chemistry,2008年,Vol.51, No.6,p.1831-1841
Bioorganic & Medicinal Chemistry,1995年,Vol.3, No.6,p.823-838
Organic & Biomolecular Chemistry,2012年,Vol.10,p.6350-6362
Chem. Pharm. Bull.,1987年,Vol.35, No.3,p.986-995

Attorney, Agent or Firm:

Atsushi Aoki
Takashi Ishida
Fukumoto product
Tetsuji Koga
Yoichi Watanabe
Ryotaro Takei
Junji Shibata

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