Title:
コア2GLCNAC-T阻害剤
Document Type and Number:
Japanese Patent JP2009500385
Kind Code:
A
Abstract:
A method of treating a subject in need of therapy for a condition involving detrimental activity of the enzyme core 2 GlcNAc-T is provided, comprising administration of a therapeutically effective amount of an inhibitor of core 2 GlcNAc-T of formula I to a patient in need thereof wherein: R1 is H, C1-6 alkyl, C1-6 hydroxyalkyl, C1-6 alkoxy or C1-6-alkoxy-C1-6-alkyl; R2 is H, -OH or C1-6 alkoxy; S1 and S2 are independently selected saccharide moieties; and Z is a steroid moiety; or a pharmaceutically acceptable salt, ether or ester thereof.
Inventors:
Chiver, Rakesh
Russell Hargan
Russell Hargan
Application Number:
JP2008519993A
Publication Date:
January 08, 2009
Filing Date:
July 06, 2006
Export Citation:
Assignee:
BTG International Limited
International Classes:
A61K45/00; A23L33/00; A61K31/704; A61K31/7048; A61P1/00; A61P1/04; A61P1/16; A61P1/18; A61P7/02; A61P9/00; A61P9/10; A61P11/06; A61P13/12; A61P17/06; A61P19/02; A61P21/00; A61P25/00; A61P27/02; A61P29/00; A61P31/04; A61P31/12; A61P31/18; A61P35/00; A61P35/04; A61P37/02; A61P37/04; A61P37/06; A61P37/08; A61P43/00; C07J7/00; C07J9/00; C07J17/00; C07J71/00
Domestic Patent References:
| JP2007515466A | 2007-06-14 | |||
| JP2009500386A | 2009-01-08 |
Other References:
JPN6011063814; Ａｒｃｈ Ｐｈａｒｍ Ｒｅｓ Ｖｏｌ．２２, 1999, ｐｐ．３１３-６
JPN6011063817; Ｐｈｙｔｏｔｈｅｒ Ｒｅｓ Ｖｏｌ．１７, 2003, ｐｐ．６２０-６
JPN6011063817; Ｐｈｙｔｏｔｈｅｒ Ｒｅｓ Ｖｏｌ．１７, 2003, ｐｐ．６２０-６
Attorney, Agent or Firm:
Kazuo Shamoto
Shinjiro Ono
Yasushi Kobayashi
Akio Chiba
Hiroyuki Tomita
Reiko Izumiya
Shinjiro Ono
Yasushi Kobayashi
Akio Chiba
Hiroyuki Tomita
Reiko Izumiya