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Title:
CORTICOID 17,21-DICARBOXYLIC ESTER AND CORTICOSTEROID 17-CARBOXYLIC ESTER 21-CARBONIC ESTER, PREPARATION THEREOF AND PHARMACEUTICAL CONTAINING THESE COMPOUNDS
Document Type and Number:
Japanese Patent JPH07165788
Kind Code:
A
Abstract:

PURPOSE: To obtain the subject novel compound which is obtained by allowing corticoid, corticosteroid or the like to undergo esterification with an activated carboxylic acid, has a strong topical or local anti-inflammatory activity and is useful as a therapeutic agent for inflammatory dermatosis.

CONSTITUTION: A corticoid 17,21-dicarboxylic ester or corticoid 17-carboxylic ester 21-carbonic ester of formula III which has a strong topical or local anti- inflammatory activity and is useful as a therapeutic agent for inflammatory dermatosis, is obtained, e.g. by allowing a compound of formula I [wherein A is CHOH, CHCl, CH2 or a C=0 or 9benzyl; R(3) is H, α- or β-methyl; and R(5) is OH] to react with a carboxylic acid offormula II [wherein R(1) is (substituted) aryl, hetaryl, 1-4C alkyl or the like; R(6) is Cl,Br, the formula: OC(O)CF3 or the like; and m and n are each 0 or 1].


Inventors:
Stache, Ulrich
Alpermann, Hans-georg
Duerckheimer, Walter
Bohn, Manfred
Application Number:
JP1994000263234
Publication Date:
June 27, 1995
Filing Date:
October 04, 1994
Export Citation:
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Assignee:
HOECHST AG
International Classes:
A61K31/57; A61K31/56; A61K31/573; A61K31/58; A61P17/00; A61P29/00; C07J5/00; C07J17/00; C07J31/00; C07J33/00; C07J41/00; C07J43/00; C07J75/00; (IPC1-7): C07J5/00; A61K31/57; C07J75/00
Attorney, Agent or Firm:
高木 千嘉 (外2名)