Corticosteroid for the medical treatment of an arthritic pain

Japanese Patent JP6247720

B2

Corticosteroid microparticle formulations are provided for use for treating pain, including pain caused by inflammatory diseases such as osteoarthritis or rheumatoid arthritis, and for slowing, arresting or reversing structural damage to tissues caused by an inflammatory disease, for example damage to articular and/or peri-articular tissues caused by osteoarthritis or rheumatoid arthritis. Corticosteroid microparticle formulations are administered locally as a sustained release dosage form (with or without an immediate release component) that results in efficacy accompanied by clinically insignificant or no measurable effect on endogenous Cortisol production.

JPH07206759	INTERMEDIATE FOR SYNTHESIZING NEW 7BETA-SUBSTITUTED-4-AZA-5ALPHA-CHOLESTANONE BEING 5ALPHA-REDUCTASE INHIBITOR
WO/2004/105731	NASAL FORMULATIONS INCLUDING A TOPICAL DECONGESTANT AND A TOPICAL CORTICOSTEROID AND THEIR USE IN TREATMENT OF OBSTRUCTIVE SLEEP APNEA
WO/1994/024146	NOVEL ANDROGENS AND ANABOLIC AGENTS

Bodick Neil
Blanks Robert Sea.
Kumar Anjali
Clayman Michael Dee.
Moran mark

JP2016119456A

December 13, 2017

June 16, 2016

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Flexion Therapeutics Incorporated

A61K31/58; A61K9/16; A61K31/56; A61K47/34; A61P19/02; A61P19/06; A61P29/00

JP9504026A
JP2005502674A
JP2004516263A
JP2009545563A
JP2001504439A

WO2011084518A1
WO2010085609A1
WO1999012571A1

Journal of Controlled Release,2009年,Vol.133,p.37-43

Hatsushi Shimizu
Masao Haruna
Hirotaka Yamaguchi
Toshi Gobe
Ryuichi Inoue
Toshimitsu Sato
Koichi Niimi
Tomohiko Kobayashi
Masato Ozeki
Yoshihiro Igarashi
Kazuya Kawamoto

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