Title:
コルチコトロピン放出因子レセプタ2欠失マウスとその利用
Document Type and Number:
Japanese Patent JP2004534508
Kind Code:
A
Abstract:
The present invention provides transgenic mice deficient in corticotropin releasing factor receptor 2 (CRFR2). Mice deficient for CRFR1 exhibit decreased anxiety-like behavior and a decreased stress response. In contrast, CRFR2 null mutant mice are hypersensitive to stress and display increased anxiety-like behavior. These mice are useful for the study of anxiety, depression, and the physiology of the HPA axis. CRFR2 null mutant mice also exhibit increased angiogenesis in all tissues examined. Thus, CRFR2 antagonists may be used to stimulate angiogenesis for the treatment of various conditions. In contrast, CRFR2 agonists may be used to inhibit angiogenesis. A combination of urocortin and bFGF was observed to stimulate rapid hair growth.
Inventors:
Lee, Quo-fan
Weil, Vail
Vail, Tracy, Elle.
Smith, George, W.
Weil, Vail
Vail, Tracy, Elle.
Smith, George, W.
Application Number:
JP2002543012A
Publication Date:
November 18, 2004
Filing Date:
November 15, 2001
Export Citation:
Assignee:
RESEARCH DEVELOPMENT FOUNDATION
International Classes:
A01K67/027; A61K31/7088; A61K38/04; A61K38/22; A61K45/00; A61K48/00; A61K49/00; A61P1/00; A61P3/10; A61P5/00; A61P5/44; A61P5/46; A61P9/00; A61P9/10; A61P13/12; A61P15/00; A61P17/14; A61P25/00; A61P35/00; C07K14/50; C07K14/72; C12N5/07; C12N5/10; C12N15/09; C12N15/85; G01N33/15; G01N33/50; A61K38/00; (IPC1-7): C12N15/09; A01K67/027; A61K31/7088; A61K38/04; A61K38/22; A61K45/00; A61K48/00; A61P1/00; A61P3/10; A61P5/00; A61P5/44; A61P5/46; A61P9/00; A61P9/10; A61P13/12; A61P15/00; A61P17/14; A61P25/00; A61P35/00; C12N5/06; C12N5/10; G01N33/15; G01N33/50
Attorney, Agent or Firm:
Igarashi Kazutoshi
Morio Sada
Morio Sada