Title:
ＩＬ１３Ｒα２を標的とする共刺激性キメラ抗原受容体Ｔ細胞
Document Type and Number:
Japanese Patent JP7171871
Kind Code:
B2
Abstract:
Chimeric transmembrane immunoreceptors (CAR) which include an extracellular domain that includes IL-13 or a variant thereof that binds interleukin-13Ra2 (IL13Ra2), a transmembrane region, a costimulatory domain and an intracellular signaling domain are described.
Inventors:
Brown, Christine E
Forman, Stephen Jay
Armen, Mardi Ross
Forman, Stephen Jay
Armen, Mardi Ross
Application Number:
JP2021169396A
Publication Date:
November 15, 2022
Filing Date:
October 15, 2021
Export Citation:
Assignee:
City of Hope
International Classes:
C12N15/62; A61K35/17; A61K38/16; A61P35/00; C07K19/00; C12N5/0783; C12N5/10
Domestic Patent References:
| JP2012501180A | ||||
| JP2009515555A |
Foreign References:
| WO2014031687A1 | ||||
| WO2010065818A1 | ||||
| WO2012079000A1 |
Other References:
Journal for ImmunoTherapy of Cancer,2013年,Vol.1, No.Suppl.1,P18
Clin. Cancer Res.,2012年,Vol.18,pp.5949-5960
Clin. Cancer Res.,2012年,Vol.18,pp.5949-5960
Attorney, Agent or Firm:
Tadashige Ito
Tadahiko Ito
Shinsuke Onuki
Tadahiko Ito
Shinsuke Onuki