PURPOSE: To improve the swelling property by cross-linking hyaluronic acid (salt) and a specified hydrophilic polymer in a diluted alkali aqueous solution under the presence of divinyl sulfone.
CONSTITUTION: To a mixture of 5-05 wt.% of a hyaluronic acid (salt) having a molecular weight of 50000-8×108 and 95-5 wt.% of the other hydrophilic polymer having a functional group reactable with divinyl sulfone (e.g.; hydroxyethyl cellulose), divinylsulfone as cross-linking agent and, as occasion demands, an inert water-insoluble material (e.g.; PE) are added to perform a cross-linking reaction in a diluted alkali aqueous solution having a pH of 9 or more at room temperature to 20°C to obtain a cross-linked hyaluronic acid gel composition having a total concentration of hyaluronic acid (salt) and hydrophilic polymer of 1-8 wt.%.
ADORUFU RESHISHINAA
