Title:
ALX受容体及び/又はFPRL2アゴニストとしての架橋スピロ[2.4]ヘプタン誘導体
Document Type and Number:
Japanese Patent JP5510945
Kind Code:
B2
Abstract:
The present invention relates to bridged spiro[2.4]heptane derivatives of formula (I), wherein W, Y, Z, R1 and R2 are as defined in the description, their preparation and their use as pharmaceutically active compounds as ALX receptor and/or FPRL2 agonists for the treatment of inflammatory and obstructive airways diseases.
Inventors:
Daniel Bull
Olivier Korminbouf
Silvene Clen
Corinna grisostomie
Xavier Leroy
Sylvia Richard-Bilstein
Olivier Korminbouf
Silvene Clen
Corinna grisostomie
Xavier Leroy
Sylvia Richard-Bilstein
Application Number:
JP2012511389A
Publication Date:
June 04, 2014
Filing Date:
May 17, 2010
Export Citation:
Assignee:
Actelion Pharmaceuticals Ltd
International Classes:
A61K31/165; C07C233/59; A61K31/167; A61K31/18; A61K31/275; A61K31/341; A61K31/397; A61K31/40; A61K31/4015; A61K31/4025; A61K31/4045; A61K31/415; A61K31/417; A61K31/4184; A61K31/4196; A61K31/42; A61K31/422; A61K31/4245; A61K31/426; A61K31/427; A61K31/428; A61K31/433; A61K31/44; A61K31/4402; A61K31/4439; A61K31/4453; A61K31/4462; A61K31/4465; A61K31/4468; A61K31/495; A61K31/496; A61K31/497; A61K31/506; A61K31/5377; A61K31/551; A61P9/00; A61P11/00; A61P21/02; A61P21/04; A61P25/00; A61P25/04; A61P25/08; A61P25/14; A61P25/28; A61P29/00; A61P31/12; A61P37/02; A61P37/06; A61P37/08; A61P43/00; C07C233/60; C07C233/61; C07C233/62; C07C233/63; C07C237/22; C07C237/24; C07C255/29; C07C271/20; C07C311/46; C07C323/40; C07D205/04; C07D207/06; C07D207/08; C07D207/09; C07D207/10; C07D207/14; C07D207/27; C07D209/08; C07D209/42; C07D211/14; C07D211/26; C07D211/56; C07D211/58; C07D211/62; C07D213/40; C07D213/75; C07D213/82; C07D231/12; C07D231/14; C07D233/36; C07D233/61; C07D233/64; C07D235/14; C07D235/24; C07D239/42; C07D241/20; C07D249/08; C07D261/08; C07D261/14; C07D261/18; C07D271/12; C07D277/20; C07D277/28; C07D277/30; C07D277/44; C07D277/56; C07D277/58; C07D277/62; C07D277/82; C07D285/13; C07D285/135; C07D295/12; C07D295/18; C07D307/14; C07D307/52; C07D333/28; C07D333/36; C07D417/12
Domestic Patent References:
| JP2007516434A |
Other References:
Bannenberg, Gerard L.,Anti-inflammatory actions of lipoxins,Expert Opinion on Therapeutic Patents,2007年,17(6),591-605
Buerli, Roland W. et al.,Potent hFPRL1 (ALXR) agonists as potential anti-inflammatory agents,Bioorganic and Medicinal Chemistry Letters ,2006年,16(14),3713-3718
Edwards, Bruce S. et al.,Integration of virtual screening with high-throughput flow cytometry to identify novel small molecule formylpeptide receptor antagonists,Molecular Pharmacology ,2005年,68(5),1301-1310
Buerli, Roland W. et al.,Potent hFPRL1 (ALXR) agonists as potential anti-inflammatory agents,Bioorganic and Medicinal Chemistry Letters ,2006年,16(14),3713-3718
Edwards, Bruce S. et al.,Integration of virtual screening with high-throughput flow cytometry to identify novel small molecule formylpeptide receptor antagonists,Molecular Pharmacology ,2005年,68(5),1301-1310
Attorney, Agent or Firm:
Mitsue Obuchi
Yukio Fuse
Yukio Fuse