Title:
β-ラクタム系抗菌薬の活性を増強する橋かけ型リポ糖ペプチド関連出願の相互参照該当なし
Document Type and Number:
Japanese Patent JP2013522204
Kind Code:
A
Abstract:
The present invention provides novel lipoglycopeptide compounds which are Type 1 signal peptidase inhibitors (SpsB). Compounds of the present invention are useful for the treatment of various bacterial related infectious diseases, particularly when used as a potentiator of a beta-lactam antibiotic such as imipenem and ertapenem. Accordingly, the present invention provides a method for the treatment of bacterial related infections using the compounds described herein, either alone or in combination with a beta-lactam antibiotic.
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Inventors:
Gilant, Michael
Veilneuve, Carine
Beaulieu, Patrick
Robichyo, Joel
Helen
Gallo, eve
Waddell, Sherman Tay
Kevin, Nancy
Gu, Shin
Hoover, Giyoan
Salvator, Michael Jei Giunia
Wilson, Kenneth
Smith, Scott Kay
Zinc, Deborah
Veilneuve, Carine
Beaulieu, Patrick
Robichyo, Joel
Helen
Gallo, eve
Waddell, Sherman Tay
Kevin, Nancy
Gu, Shin
Hoover, Giyoan
Salvator, Michael Jei Giunia
Wilson, Kenneth
Smith, Scott Kay
Zinc, Deborah
Application Number:
JP2012557119A
Publication Date:
June 13, 2013
Filing Date:
March 04, 2011
Export Citation:
Assignee:
Merck Sharp End Dome Corporation
International Classes:
A61K38/08; C07K5/023; A61K31/201; A61K31/397; A61K31/407; A61K31/43; A61K31/545; A61K38/00; A61K45/00; A61P31/04; A61P43/00
Attorney, Agent or Firm:
Yoshikazu Iwase
Makoto Ono
Kenkyo Kanayama
Mitsuaki Tsubokura
Kazuki Shigemori
Kenji Ando
Yasufumi Shiroyama
Makoto Ono
Kenkyo Kanayama
Mitsuaki Tsubokura
Kazuki Shigemori
Kenji Ando
Yasufumi Shiroyama