CROSSLINKED POLYVINYLAMINE, POLYALLYLAMINE, AND POLYETHYLENIMINE FOR USING AS BILE ACID SCAVENGER

Title:

CROSSLINKED POLYVINYLAMINE, POLYALLYLAMINE, AND POLYETHYLENIMINE FOR USING AS BILE ACID SCAVENGER

Document Type and Number:

Japanese Patent JP2015038225

Kind Code:

A

Abstract:

PROBLEM TO BE SOLVED: To provide a crosslinked amine polymer or amide polymer effective for removing a bile acid salt from a gastrointestinal tract by being bonded with a bile acid salt.SOLUTION: The present invention provides a crosslinked amine polymer or amide polymer effective for removing a bile acid salt from a gastrointestinal tract by being bonded with a bile acid salt. By administering such a polymer bonded with bile acid or a pharmaceutical composition thereof to a subject, various conditions including hypercholesterolemia, diabetes, pruritus, irritable bowel syndrome - diarrhea (IBS-D), and bile acid malabsorption can be healed. The present invention relates generally to a polymer useful for being bonded with bile acid in a gastrointestinal tract of a patient requiring the removal of bile acid therefrom. The polymer and the pharmaceutical composition thereof are useful in a patient requiring the reduction of the cholesterol concentration thereof for reducing cholesterol, specifically non-high-density lipoprotein (non-HDL) cholesterol, or more specifically, low-density lipoprotein (LDL) cholesterol.

Inventors:

JORDON KOPPING
KALPESH BIYANI
ERIC CONNOR
SCOTT HECKER
INEZ LEES
GRACE QUAKER
FALEH SALAYMEH
ZHANG HONGMIN
DAVID BERGBREITER
MANSKY PAUL
MU YONGQI
COPE MICHAEL JAMES
ELIZABETH GOKA
LEE ANGELA
DEIDRE MADSEN
SHAO JUN

Application Number:

JP2014237462A

Publication Date:

February 26, 2015

Filing Date:

November 25, 2014

Export Citation:

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Assignee:

ILYPSA INC

International Classes:

C08F126/02; A61K31/155; A61K31/192; A61K31/216; A61K31/22; A61K31/366; A61K31/397; A61K31/40; A61K31/404; A61K31/427; A61K31/4418; A61K31/4439; A61K31/455; A61K31/47; A61K31/4985; A61K31/505; A61K31/517; A61K31/56; A61K31/64; A61K31/785; A61K38/00; A61K38/22; A61K38/28; A61K45/00; A61K45/06; A61P1/04; A61P1/16; A61P3/06; A61P3/10; A61P9/00; A61P17/04; A61P25/28; C08F20/52; C08F220/60; C08G73/04

Attorney, Agent or Firm:

Shusaku Yamamoto
Natsuki Morishita

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