Title:
噴霧化利用の結晶システム
Document Type and Number:
Japanese Patent JP2005523811
Kind Code:
A
Abstract:
Crystallization of an organic pharmaceutical compound is achieved by atomization of one solution and introduction of the atomized solution into a vessel containing a second solution where the solutions are mixed to form a product. The process can be performed on non-reactive constituents such as a solution containing the compound to be crystallized dissolved in a solvent and an anti-solvent solution. Alternatively, the process can be performed on reactive constituents, such as solutions of solvents containing different reactive intermediates, under proper reactive conditions. The process may be practiced continuously or in batch mode. Atomizers of the non-pressure-driven ultrasonic type or of the ultrasonic or non-ultrasonic pressure-driven type can be utilized.
Inventors:
Changkou way
Otute Aquity
Margaret M Gleason
Otute Aquity
Margaret M Gleason
Application Number:
JP2004501029A
Publication Date:
August 11, 2005
Filing Date:
April 21, 2003
Export Citation:
Assignee:
BRISTOL-MYERS SQUIBB COMPANY
International Classes:
A61K9/16; B01D9/00; B01F3/08; B01D9/02; B01F5/02; B01F15/02; B01J19/00; B01J19/10; B01J19/18; B01J19/24; B01J19/26; C07D263/00; B01F7/00; B01F7/16; (IPC1-7): B01D9/02; B01F3/08; B01F15/02
Attorney, Agent or Firm:
Kyousei Tamura
Nagatoshi Shinagawa
Nagatoshi Shinagawa