Title:
結晶形の(20R,25S)-2-メチレン-19,26-ジノル-1α,25-ジヒドロキシビタミンD3
Document Type and Number:
Japanese Patent JP2013540764
Kind Code:
A
Abstract:
A method of purifying (20R,25S)-2-methylene-19,26-dinor-1α,25-dihydroxyvitamin D3 to obtain (20R,25S)-2-methylene-19,26-dinor-1α,25-dihydroxyvitamin D3 in crystalline form. The method includes the steps of preparing a solvent of methanol and water, dissolving a product containing (20R,25S)-2-methylene-19,26-dinor-1α,25-dihydroxyvitamin D3 to be purified in the solvent, cooling the solvent and dissolved product below ambient temperature for a sufficient amount of time to form a precipitate of (20R,25S)-2-methylene-19,26-dinor-1α,25-dihydroxyvitamin D3 crystals, and recovering the (20R,25S)-2-methylene-19,26-dinor-1α,25-dihydroxyvitamin D3 crystals.
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Inventors:
Deluca Hector F.
Guzi Vachu Purwell
Todan James Bee.
Holden Hazel M.
Guzi Vachu Purwell
Todan James Bee.
Holden Hazel M.
Application Number:
JP2013531770A
Publication Date:
November 07, 2013
Filing Date:
September 28, 2011
Export Citation:
Assignee:
Wisconsin Alumni Research Foundation
International Classes:
C07C401/00; C07C29/78; C07C35/21
Attorney, Agent or Firm:
Hatsushi Shimizu
Masao Haruna
Hirotaka Yamaguchi
Toshi Gobe
Ryuichi Inoue
Toshimitsu Sato
Koichi Niimi
Tomohiko Kobayashi
Shinichi Watanabe
Masato Ozeki
Yoshihiro Igarashi
Kazuya Kawamoto
Masao Haruna
Hirotaka Yamaguchi
Toshi Gobe
Ryuichi Inoue
Toshimitsu Sato
Koichi Niimi
Tomohiko Kobayashi
Shinichi Watanabe
Masato Ozeki
Yoshihiro Igarashi
Kazuya Kawamoto