Crystalline N-{(1S) -2-amino-1-[(3-fluorophenyl) methyl] ethyl} -5-chloro-4- (4-chloro-1-methyl-1H-pyrazole-5-yl) -2-Thiophene carboxamide hydrochloride

Title:

Crystalline N-{(1S) -2-amino-1-[(3-fluorophenyl) methyl] ethyl} -5-chloro-4- (4-chloro-1-methyl-1H-pyrazole-5-yl) -2-Thiophene carboxamide hydrochloride

Document Type and Number:

Japanese Patent JP6328590

Kind Code:

B2

Abstract:

An improved AKT inhibiting compound, crystalline Λ/-{(1S)-2-amino-1-[(3-fluorophenyl)methyl]ethyl}-5-chloro-4-(4-chloro-1-methyl-1 H-pyrazol-5-yl)-2-thiophenecarboxamide hydrochloride.

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Inventors:

Pin Yun, Wai Chen
Jeffrey, Golding

Application Number:

JP2015114505A

Publication Date:

May 23, 2018

Filing Date:

June 05, 2015

Export Citation:

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Assignee:

Novartis Age

International Classes:

C07D409/04; A61K31/282; A61K31/337; A61K31/4155; A61K31/475; A61K45/00; A61P19/02; A61P35/00; A61P35/02; A61P43/00

Foreign References:

WO2008098104A1

Other References:

JOURNAL OF PHARMACEUTICAL SCIENCES,1997,VOL.86,NO.1,PP.1-12
PHARMACEUTICAL RESEARCH,1995,VOL.12,NO.7,PP.945-954
INTERNATIONAL JOURNAL OF PHARMACEUTICS,1990,VOL.62,NO.2-3,PP.87-95

Attorney, Agent or Firm:

Hiroshi Kobayashi
Eiji Katayama
Norio Omori
Kyoko Tamura
Yasuhito Suzuki

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