Title:
CRYSTALLINE DIHYDRATE OF CEPHALOSPORIN DIHYDROCHLORIDE AND ITS COMPOSITION FOR INJECTION
Document Type and Number:
Japanese Patent JP3868008
Kind Code:
B2
Abstract:
PURPOSE: To obtain a new temp. and moisture stable compd. useful as a compsn. for injection.
CONSTITUTION: This dihydrate of 7-[α-(2-aminothiazol-4-yl)-α-(Z)- methoxyiminoacetamide)-3-[(1-methyl-1-pyrrolidino)methyl]-3-cephem-4- carboxylate dihydrochloride of the formula is obtained by adding triethylamine to 7-amino-3-[(1-methyl-1-pyrrolidinio)methyl]ceph-3-em-4-carboxylate hydrochloride and syn-2-(2-aminothiazol-4-yl)-2-methoxyiminoacetylchloride hydrochloride and reacting them at -20 to -30°C.
Inventors:
Elizabeth Ann Garofalo
Gallie FM rim
Murray Arthur Kaplan
Manil N NASA
Gallie FM rim
Murray Arthur Kaplan
Manil N NASA
Application Number:
JP25205593A
Publication Date:
January 17, 2007
Filing Date:
September 02, 1993
Export Citation:
Assignee:
BRISTOL-MYERS SQUIBB COMPANY
International Classes:
A61K9/08; A61K31/545; C07D501/56; A61K31/546; A61K47/16; A61P31/04; C07D501/00; C07D501/46; (IPC1-7): C07D501/56; A61K9/08; A61K31/545; A61K47/16
Domestic Patent References:
| JP2009885A |
Attorney, Agent or Firm:
Takehiko Saito