Title:
CRYSTALLINE FORM OF QUINOLINONE-CARBOXAMIDE COMPOUND
Document Type and Number:
Japanese Patent JP2012153725
Kind Code:
A
Abstract:
To provide crystalline salt forms of a quinolinone-carboxamide compound which are useful as 5-HT4 receptor agonists.
There are provided a crystalline hydrochloride salt of 1-isopropyl-2-oxo-1,2-dihydroquinoline-3-carboxylic acid {(1S,3R,5R)-8-[(R)-2-hydroxy-3-(methanesulfonyl-methyl-amino)propyl]-8-azabicyclo[3.2.1]oct-3-yl}amide or a solvate thereof. There are also provided pharmaceutical compositions comprising such crystalline salt forms, methods of using such crystalline salt forms to treat diseases associated with 5-HT4 receptor activity, and processes useful for preparing such crystalline salt forms.
Inventors:
FATHEREE PAUL R
TURNER S DEREK
GOLDBLUM ADAM
CHAO ROBERT
GENOV DANIEL
TURNER S DEREK
GOLDBLUM ADAM
CHAO ROBERT
GENOV DANIEL
Application Number:
JP2012113464A
Publication Date:
August 16, 2012
Filing Date:
May 17, 2012
Export Citation:
Assignee:
THERAVANCE INC
International Classes:
C07D451/04; A61K31/4709; A61P1/04; A61P1/10; A61P43/00
Attorney, Agent or Firm:
Hidesaku Yamamoto
Takaaki Yasumura
Natsuki Morishita
Takaaki Yasumura
Natsuki Morishita