Title:
CRYSTALLINE FORM OF UREA COMPOUND ANTAGONIZING LPA1 RECEPTOR, AND PRODUCTION METHOD THEREOF
Document Type and Number:
Japanese Patent JP2022115835
Kind Code:
A
Abstract:
To provide stable crystalline forms in use environment of a urea compound which antagonizes an LPA1 receptor as a medicine, and a production method thereof.SOLUTION: The problem is solved by a crystal of a N-methyl-D-glucamine salt hydrate of trans-1-[([(1R)-1-(4-acetyl-2-chloro-3,5-diethoxyphenyl)ethyl]{2-[(1S)-1-phenylethoxy]ethyl}carbamoyl)amino]-3-ethoxycyclobutane-1-carboxylic acid (a) having peaks at 2θ=3.5°, 8.1°, 10.1°, and 14.6°in powder X-ray diffractometry (Cu-Kα), (b) having characteristic absorption bands of 1610 cm-1, 1556 cm-1, 1412 cm-1, and 1075 cm-1 in infrared absorption spectroscopy (ATR method), and (c) having endothermic peaks of 45°C-55°C, and 70°C-79°C in differential thermal analysis/thermal mass measurement (TG/DTA).SELECTED DRAWING: Figure 1
Inventors:
HATANAKA KANAKO
UEHARA YUKO
SUZUKI AKINORI
UEHARA YUKO
SUZUKI AKINORI
Application Number:
JP2022010559A
Publication Date:
August 09, 2022
Filing Date:
January 27, 2022
Export Citation:
Assignee:
TAISHO PHARMACEUTICAL CO LTD
International Classes:
C07C215/10; C07C275/26; C07C273/18