Title:
CRYSTALLINE FORMS OF [R-(R*,R*)]-2-(4-FLUOROPHENYL)-BETA, DELTA-DIHYDROXY-5-(1-METHYLETHYL)-3-PHENYL-4-[PHENYLAMINO]CARBONYL]-1H-PYRROLE-1-HEPTANOIC ACID CALCIUM SALT (2:1) (ATORVASTATIN)
Document Type and Number:
Japanese Patent JP2007182460
Kind Code:
A
Abstract:
To provide a pharmaceutical composition of the same, which are useful as agents for treating hyperlipidemia, hypercholesterolemia, osteoporosis, and Alzheimer's disease.
Novel crystalline forms of [R-(R*,R*)]-2-(4-fluorophenyl)-β, Δ-dihydroxy-5-(1-methylethyl)-3-phenyl-4-[(phenylamino)carbonyl]-1H-pyrrole-1-heptanoic acid hemi calcium salt (atorvastatin) designed form X or form XII are characterized by their X-ray powder diffraction, solid-state NMR, and/or Raman spectroscopy.
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Inventors:
BYRN STEPHEN ROBERT
COATES DAVID ANDREW
GUSHURST KAREN SUE
MORRISON HENRY GRANT II
PARK AERI
VLAHOVA PETINKA IVANOVA
LI ZHENG JANE
KRZYZANIAK JOSEPH FRANCIS
COATES DAVID ANDREW
GUSHURST KAREN SUE
MORRISON HENRY GRANT II
PARK AERI
VLAHOVA PETINKA IVANOVA
LI ZHENG JANE
KRZYZANIAK JOSEPH FRANCIS
Application Number:
JP2007103465A
Publication Date:
July 19, 2007
Filing Date:
April 11, 2007
Export Citation:
Assignee:
WARNER LAMBERT CO
International Classes:
C07D207/34; A61K31/40; A61P3/06; A61P19/10; A61P25/28
Foreign References:
| WO2001036384A1 | 2001-05-25 |
Attorney, Agent or Firm:
Chika Takagi
Junji Yuda
Shoji Miwa
Junji Yuda
Shoji Miwa