Title:
CRYSTALLINE HEMI-TARTRATE OF [5-(4,6-DIMETHYL-1H-BENZOIMIDAZOL-2-YL)-4-METHYL-PYRIMIDIN-2-YL]-4-METHYL-PYRIMIDIN-2-YL]-[3-(1-METHYL-PIPERIDIN-4-YL)-PROPYL]-AMINE
Document Type and Number:
Japanese Patent JP2014040426
Kind Code:
A
Abstract:
To provide a benzoimidazol-2-yl pyrimidine derivative useful as a histamine H4 receptor modulator, and a method for producing the compound..
There is provided a method for producing a hemi-tartrate of a compound of formula (I-A). The method includes: dissolving the compound of the formula (I-A) into an organic solvent to produce a solution; heating the solution at a first temperature in the range of about 35°C to about reflux temperature; adding L-tartaric acid thereto to produce a tartrate solution; and heating the tartrate solution to a second temperature in the range of about 50°C to about reflux temperature to produce the heated mixture.
Inventors:
CESCO-CANCIAN SERGIO
GRIMM JEFFREY S
NEELAKANDHA S MANI
MAPES CHRISTOPHER M
DAVID C PALMER
PIPPEL DANIEL J
XIAO TONG
DIEGO BROGGINI
LOCHNER SUSANNE
GRIMM JEFFREY S
NEELAKANDHA S MANI
MAPES CHRISTOPHER M
DAVID C PALMER
PIPPEL DANIEL J
XIAO TONG
DIEGO BROGGINI
LOCHNER SUSANNE
Application Number:
JP2013186044A
Publication Date:
March 06, 2014
Filing Date:
September 09, 2013
Export Citation:
Assignee:
JANSSEN PHARMACEUTICA NV
International Classes:
C07D401/14
Domestic Patent References:
| JP2007507511A | 2007-03-29 | |||
| JP2007530570A | 2007-11-01 |
Foreign References:
| WO2007117400A2 | 2007-10-18 | |||
| WO2007117399A2 | 2007-10-18 |
Attorney, Agent or Firm:
Patent business corporation Odashima patent office