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Patent Searching and Data


Title:
CRYSTALLINE AND PURE MODAFINIL AND PROCESS FOR PREPARING THE SAME
Document Type and Number:
Japanese Patent JP2009024006
Kind Code:
A
Abstract:

To provide an improved process for preparing modafinil, whereby it may be isolated in high purity by a single operation of crystallization.

The present process can be used for producing modafinil which is free of sulfone products by over-oxidation and other byproducts. The invention further provides new crystalline forms II-VI of modafinil and processes for preparing them. Each of the new forms is differentiated by a unique powder X-ray diffraction pattern. The invention further provides pharmaceutical compositions containing novel modafinil forms II-IV and VI.


Inventors:
Singer, Claude
Gershon, Neomi
Ceausu, Arina
Lieberman, Anita
Aronhime, Judith
Application Number:
JP2008000179304
Publication Date:
February 05, 2009
Filing Date:
July 09, 2008
Export Citation:
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Assignee:
TEVA PHARMACEUTICAL INDUSTRIES LTD
International Classes:
C07C315/02; A61K31/16; A61K31/165; A61P25/18; C07C315/06; C07C317/44; C30B7/00; C07B61/00; A61K; C07C
Domestic Patent References:
JPS53121724A1978-10-24
JPS62190160A1987-08-20
Attorney, Agent or Firm:
青木 篤
石田 敬
福本 積
古賀 哲次
渡辺 陽一
中村 和広
中島 勝