Title:
CRYSTALLINE SALT OF -LIPOIC ACID AND L-LYSINE, AND METHOD FOR PREPARING THE SAME
Document Type and Number:
Japanese Patent JP2008156281
Kind Code:
A
Abstract:
To provide a high purity crystalline salt of -lipoic acid and L-lysine, and an industrial method for preparing the same.
The industrial method for preparing a high purity crystalline salt of -lipoic acid and L-lysine comprises gradually dripping an aqueous ethanol solution of L-lysine of a temperature of 0 to 10C into an ethanol solution of -lipoic acid of a temperature of 0 to 10C, stirring the mixed solution at the same temperature as above, isolating precipitated crystals by a commonly known method, and drying the isolated crystals at a temperature of 40C or lower under vacuum. Thus obtained salt of -lipoic acid and L-lysine shows a melting temperature of 149 to 151C and shows crystallinity by X-ray diffractometry.
Inventors:
SHISHIDO MASAHIKO
UENO KOICHI
NAKAGAMI YUICHI
MORIWAKI HIROKI
UENO KOICHI
NAKAGAMI YUICHI
MORIWAKI HIROKI
Application Number:
JP2006347031A
Publication Date:
July 10, 2008
Filing Date:
December 25, 2006
Export Citation:
Assignee:
HAMARI CHEMICALS LTD
International Classes:
C07D339/04; A61P1/00; A61P39/02; B01D9/02; A61K31/385
Attorney, Agent or Firm:
Akaoka Michio
Kazuo Akaoka
Kazuo Akaoka