Title:
CRYSTALLIZATION OF CEPHALOSPORIN COMPOUND
Document Type and Number:
Japanese Patent JP3755908
Kind Code:
B2
Abstract:
PURPOSE: To obtain crystals of the subject compound excellent in fluidity, filling property and pressure resistance regardless of origin of raw materials, its producing method, existence or absence, or king of an impurity and difference in its contents by crystallizing a cephalosporin compound in the presence of a specific habit modifier such as a water-soluble cellulose derivative.
CONSTITUTION: This crystallizing method is to crystallize a cephalosporin compound {preferably 7β-[(Z)-2-(2-amino-4-thiazolyl)-2-hydroxyiminoacetamide]-3-(1,2,3- triazol-4-yl) thiomethylthio-3-cephem-4-wcarboxylic acid-hydrochloride hydrate} from am acidic aqueous solution of pH ≤6 preferably in which an organic solvent may be included therein, in the presence of one or more habit modifiers selected from a group of a water-soluble cellulose derivative, a water-soluble starch derivative and a polyvinyl compound (preferably hydroxypropylcellulose, hydroxypropylmethyl cellulose, methylcellulose or polyvinyl pyrrolidone).
Inventors:
Hisashi Takahashi
Yoshiyuki Masui
Yoshiyuki Masui
Application Number:
JP19305994A
Publication Date:
March 15, 2006
Filing Date:
August 17, 1994
Export Citation:
Assignee:
Shionogi Pharmaceutical Co., Ltd.
International Classes:
C07D501/59; A61K31/545; A61K31/546; A61P31/04; C07B63/00; (IPC1-7): C07D501/59; //A61K31/545; C07B63/00
Domestic Patent References:
| JP6092970A |
Attorney, Agent or Firm:
Aoyama Aoi
Kyousei Tamura
Minato Saito
Nagatoshi Shinagawa
Kyousei Tamura
Minato Saito
Nagatoshi Shinagawa