Title:
プロテアーゼ阻害薬としてのシアノアルキルアミノ誘導体
Document Type and Number:
Japanese Patent JP4343690
Kind Code:
B2
Abstract:
The present invention is directed to novel cyanoalkylamino derivatives that are inhibitors of cysteine protease such as cathepsins K, S, B and L, in particular cathepsin K Pharmaceutical composition comprising these compounds, method of treating diseases mediated by unregulated cysteine protease activity, in particular cathepsin K utilizing these compounds and methods of preparing these compounds are also disclosed.
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Inventors:
Black, melon
Crane, Cieldon N
Davis, Dana
Setu Tei, Ed Waldo El
Crane, Cieldon N
Davis, Dana
Setu Tei, Ed Waldo El
Application Number:
JP2003543536A
Publication Date:
October 14, 2009
Filing Date:
November 13, 2002
Export Citation:
Assignee:
AXYS PHARMACEUTICALS, INC.
International Classes:
C07C317/44; C07D295/08; A61K31/277; A61K31/341; A61K31/381; A61K31/4164; A61K31/423; A61K31/426; A61K31/428; A61K31/4402; A61K31/4406; A61K31/4409; A61K31/4468; A61K31/455; A61K31/495; A61K31/496; A61K31/505; A61K31/5375; A61K31/663; A61K31/675; A61P1/18; A61P3/10; A61P5/14; A61P11/00; A61P11/06; A61P19/02; A61P19/10; A61P21/04; A61P25/02; A61P25/28; A61P29/00; A61P35/00; A61P37/02; A61P37/08; A61P43/00; C07C323/60; C07C323/65; C07D211/58; C07D213/32; C07D213/40; C07D213/52; C07D213/70; C07D213/74; C07D213/75; C07D213/81; C07D213/82; C07D233/84; C07D239/38; C07D263/58; C07D277/16; C07D277/20; C07D277/42; C07D277/74; C07D295/12; C07D295/18; C07D295/20; C07D307/38; C07D333/20
Domestic Patent References:
| JP9059259A | ||||
| JP1207289A | ||||
| JP2002539191A | ||||
| JP2002539192A | ||||
| JP9509921A |
Attorney, Agent or Firm:
Yoshio Kawaguchi
Makoto Ono
Kenkyo Kanayama
Katsuma Osaki
Mitsuaki Tsubokura
Akio Ichiiri
Makoto Ono
Makoto Ono
Kenkyo Kanayama
Katsuma Osaki
Mitsuaki Tsubokura
Akio Ichiiri
Makoto Ono