PURPOSE: To obtain a stable labeled protein wherein a cyanine pigment which is hardly water-soluble, is made water-soluble and a protein is labeled with a pigment by a method wherein nitrogen atoms are bonded to carbon and a carboxyl group is bonded to α carbon or an adjacent carbon main chain.
CONSTITUTION: In a (mero)cryanine pigment provided with a heterocycle provided with nitrogen atoms, the nitrogen atoms are bonded to carbon and a carboxyl group is bonded to α carbon or an adjacent carbon main chain. In order to make a cyanine pigment water-soluble and to reduce a change in the wavelength and the stability of the pigment as compared with a case where a polar group is introduced, it is preferable that the polar group is introduced directly to the nitrogen atoms in the heterocycle. When there is a possibility that a substance originated from a living body is mixed, it is required to discriminate it optically and preferably it is adsorbed in a long-wavelength region. When the conjugated system of the cyanine pigment is made long, the pigment is adsorbed by a long wavelength. When a benzene ring in the heterocycle is changed to a naphthalene ring, a wavelength can be made a little longer.
| JP4516784 | New oxonor dye compounds and optical information recording media |
| JP2003039837 | THERMAL TRANSFER SHEET |
| JPS63260487 | OPTICAL RECORDING MEDIUM |
OKAMOTO HISASHI
YAMAMOTO NOBUKO
KAWAGUCHI MASAHIRO
