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Title:
CYATHANE DERIVATIVE AND INDUCER FOR NERVE GROWTH FACTOR PRODUCTION CONTAINING THE SAME AS ACTIVE INGREDIENT
Document Type and Number:
Japanese Patent JPH0873486
Kind Code:
A
Abstract:

PURPOSE: To obtain the subject new derivative, isolated from a cultured mycelium of Hericium erinaceum Pers. which is a mushroom belonging to the genus Hericium of the family Hydnaceae, having the cyathane skeleton, capable of manifesting inducing actions on the nerve growth factor production and useful as a therapeutic agent, etc., for senile dementia.

CONSTITUTION: This new cyathane derivative represented by the formula is obtained by culturing a mycelium of Hericium erinaceum Pers. belonging to the genus Hericium of the family Hydnaceae in a culture medium for 4 weeks, centrifuging the resultant cultured product, providing a cultured mycelium which is a precipitate, then adding the cultured mycelium to an 85% aqueous solution of ethanol, carrying out the homogenizing treatment, allowing the resultant homogenate to stand at ambient temperature for 1 week, filtering the homogenate, collecting an extract solution, heating the obtained extract solution under a vacuum, evaporating the ethanol, recovering an aqueous layer, extracting the recovered aqueous layer with ethyl acetate, treating the extract by silica gel column chromatography and purifying the extract. The resultant derivative has inducing actions on the nerve growth factor production and is useful as a therapeutic agent, etc., for senile dementia.


Inventors:
SHIMADA ATSUSHI
KAWAGISHI HIROKAZU
FURUKAWA SHOEI
MORI YOSHINOBU
KOJIMA FUMIHIRO
OKAMOTO KENJI
SAKAMOTO HIDEKI
Application Number:
JP1994000234271
Publication Date:
March 19, 1996
Filing Date:
September 02, 1994
Export Citation:
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Assignee:
KAGOME KK
International Classes:
C07H15/20; A61K31/35; A61K31/70; A61K31/7028; A61K31/7034; A61K36/07; A61P25/00; A61P43/00; C07D407/12; C07D493/04; C07D493/18; C07J73/00; (IPC1-7): C07H15/20; A61K31/35; A61K31/70; A61K35/84; C07D407/12; C07D493/04; C07D493/18
Attorney, Agent or Firm:
入山 宏正