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Title:
CYCLIC AMIDE COMPOUND
Document Type and Number:
Japanese Patent JP2000191661
Kind Code:
A
Abstract:

To obtain a new cyclic amide compound useful as a selective muscarine receptor antagonist.

This cyclic amide compound is a compound of formula I [R1 is a lower cycloalkyl, a (substituted) phenyl or the like; R2 is H, a lower alkyl or a halogen; (m) is 0, 1; (n) is 2-4; Im is a group of formula II (R3 is a lower alkyl) or formula III (R4 to R6 are each H or a lower alkyl)]. For example, 3-[3-(4,5-dihydro-2-methyl-1H-imidazolyl)propyl]3-phenyl-1,3-dihydroindol-2-one. The compound of the formula I is obtained by dissolving a compound of formula IV with a dry tetrahydrofuran, ether, dioxane, diethylene glycol, dimethyl ether or the like, adding n-butyl lithium, sodium hydride, sodium amide, etc., agitating at a temp. of (-)70°C to the boiling point of the solvent, then adding a compound of formula V (X is a leaving group) and agitating at a temp. of room temperature to the boiling point of the solvent.


Inventors:
ONO TOKUO
MIURA MASATAKA
AIZAWA HIDEYUKI
Application Number:
JP1998000370262
Publication Date:
July 11, 2000
Filing Date:
December 25, 1998
Export Citation:
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Assignee:
MITSUBISHI TOKYO PHARM INC
International Classes:
C07D401/06; A61K31/00; A61K31/415; A61K31/4164; A61K31/4178; A61K31/47; A61K31/4709; A61P1/00; A61P11/00; A61P11/02; A61P11/06; A61P13/00; A61P25/04; A61P43/00; C07D403/06; (IPC1-7): C07D403/06; A61K31/4178; A61K31/4709; A61P1/00; A61P11/00; A61P11/02; A61P11/06; A61P13/00; A61P25/04; A61P43/00; C07D401/06
Attorney, Agent or Firm:
松山 直行