Title:
CYCLIC AMINE DERIVATIVE
Document Type and Number:
Japanese Patent JP2733203
Kind Code:
B2
Abstract:
PURPOSE: To obtain a new cyclic amine derivative having strong and highly highly selective anti-acetylcholine esterase activity and effective in the treatment or prophylaxis of a disease of central nervous system.
CONSTITUTION: This is a compound of formula l [J is a phenyl, a pyridyl, a cyclohexyl, an indanyl, an indanonyl, an indenyl, formula II, a lower alkyl, etc.; B is formula III to formula VI [R2 is H or methyl; R3 is H, a lower alkyl, an acyl, a phenyl, a benzyl, etc.; R4 is H, a lower alkyl or a phenyl; (n)=0-10], etc.; T is N or C; Q is N, C or N→O; K is H, a phenyl, an arylalkyl, a cinnamyl, a lower alkyl, a pyridinemethyl, a cycloal-kylalkyl, an acyl, etc.; (q)=1-3] or its pharmaceutically allowable salt, e.g. l-benzyl-4-[(5,6-dimethoxy-1- indanone)-2-yl]methylpiperidine. A compound of formula I in which B is a group of formula VI is obtained by reacting an acid halide of formula VII with a cyclic amine derivative of formula VIII.
Inventors:
SUGIMOTO HACHIRO
TSUCHA YUTAKA
HIGURE KUNIZO
KARIBE NORIO
IIMURA YOICHI
SASAKI ATSUSHI
YAMANISHI YOSHIHARU
OGURA HIROO
ARAKI SHIN
OZASA TAKASHI
KUBOTA ATSUHIKO
OZASA MICHIKO
YAMATSU KYOMI
TSUCHA YUTAKA
HIGURE KUNIZO
KARIBE NORIO
IIMURA YOICHI
SASAKI ATSUSHI
YAMANISHI YOSHIHARU
OGURA HIROO
ARAKI SHIN
OZASA TAKASHI
KUBOTA ATSUHIKO
OZASA MICHIKO
YAMATSU KYOMI
Application Number:
JP29116994A
Publication Date:
March 30, 1998
Filing Date:
November 25, 1994
Export Citation:
Assignee:
EEZAI KK
International Classes:
A61K31/40; A61K31/395; A61K31/4427; A61K31/443; A61K31/4433; A61K31/445; A61K31/4465; A61K31/451; A61K31/452; A61K31/47; A61K31/495; A61K31/50; A61K31/505; A61K31/55; A61P21/00; A61P25/02; A61P25/28; A61P43/00; C07D207/06; C07D207/09; C07D209/32; C07D211/08; C07D211/10; C07D211/18; C07D211/22; C07D211/26; C07D211/28; C07D211/30; C07D211/32; C07D211/34; C07D211/44; C07D211/70; C07D211/74; C07D211/76; C07D211/94; C07D213/24; C07D213/81; C07D215/16; C07D217/04; C07D217/24; C07D223/16; C07D235/26; C07D239/80; C07D241/24; C07D243/14; C07D243/38; C07D295/10; C07D295/12; C07D295/22; C07D307/68; C07D401/04; C07D401/06; C07D401/12; C07D405/04; C07D405/06; C07D405/12; C07D409/06; C07D413/06; C07D471/04; C07D471/06; C07D; (IPC1-7): A61K31/40; A61K31/445; A61K31/495; A61K31/505; A61K31/55; C07D211/10; C07D211/22; C07D211/26; C07D211/44; C07D401/06; C07D405/06; C07D405/12; C07D409/06; C07D413/06; C07D471/04
Domestic Patent References:
JP52156933A | ||||
JP56152475A | ||||
JP59186963A | ||||
JP60248673A | ||||
JP61227565A | ||||
JP62129258A | ||||
JP62234065A | ||||
JP62252762A | ||||
JP63239220A | ||||
JP62181253A | ||||
JP6479151A | ||||
JP2169569A | ||||
JP406347B1 | ||||
JP4521307B1 | ||||
JP5024959B1 | ||||
JP604187B2 | ||||
JP6147838B2 |
Other References:
【文献】米国特許4145347(US,A)
【文献】米国特許4734275(US,A)
【文献】欧州特許出願公開270947(EP,A)
【文献】国際公開88/2365(WO,A)
【文献】Chemical Abstracts,86(5),(1977),要約番号25873a
【文献】米国特許4734275(US,A)
【文献】欧州特許出願公開270947(EP,A)
【文献】国際公開88/2365(WO,A)
【文献】Chemical Abstracts,86(5),(1977),要約番号25873a
Attorney, Agent or Firm:
Kaoru Furuya (3 outside)
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