Title:
ケモカイン受容体活性のモジュレーターとしての環状誘導体
Document Type and Number:
Japanese Patent JP5180961
Kind Code:
B2
Abstract:
This invention relates generally to modulators of chemokine receptor activity having unexpected combination of desirable pharmacological properties. Pharmaceutical compositions containing the same, and methods of using the same as agents for treatment and prevention of inflammatory, allergic, autoimmune, metabolic, cancer and/or cardiovascular diseases, particularly diabetes, Crohn's disease, atherosclerosis, and multiple sclerosis, along with methods of preparing compounds and intermediates therefor. Metabolites of active compounds are also provided herein, pharmaceutical compositions and use thereof are also provided.
Inventors:
Percy H Carter
Robert Jay Charney
John Hines
So S Co
Anurag Srivastava
Gili Shao
Michael Gee Yang
Robert Jay Charney
John Hines
So S Co
Anurag Srivastava
Gili Shao
Michael Gee Yang
Application Number:
JP2009522953A
Publication Date:
April 10, 2013
Filing Date:
July 26, 2007
Export Citation:
Assignee:
BRISTOL-MYERS SQUIBB COMPANY
International Classes:
C07D401/12; A61K31/4439; A61K31/517; A61K31/519; A61P1/00; A61P3/04; A61P3/10; A61P9/00; A61P9/04; A61P9/10; A61P9/12; A61P17/00; A61P17/06; A61P19/02; A61P25/04; A61P25/28; A61P29/00; A61P31/18; A61P35/00; A61P37/00; C07D403/12; C07D487/04
Domestic Patent References:
| JP2009544758A | ||||
| JP2009544756A |
Foreign References:
| WO2005021500A1 | ||||
| WO2004071460A1 |
Attorney, Agent or Firm:
Kyousei Tamura
Samejima Mutsumi
Nagatoshi Shinagawa
Yasushi Morimoto
Samejima Mutsumi
Nagatoshi Shinagawa
Yasushi Morimoto