Title:
CYCLIC-OCTAPEPTIDE AND MANUFACTURE, AND MEDICINE
Document Type and Number:
Japanese Patent JPS58116444
Kind Code:
A
Abstract:
Cyclic octapeptides of the formula (I) in which Aaa represents a radical of a straight-chained alpha , omega -diaminoalkanoic acid having from 4 to 7 carbon atoms, trp represents a radical L-Trp or, especially, D-Trp, or a radical derived therefrom, which carries a halogen atom in the indole nucleus, AcA represents an acyl radical Ac of an optionally substituted carboxylic acid which is positioned at the omega -amino group, or represents an amidino group or hydrogen, and AcB represents an acyl radical Ac1 of an amino acid or of an oligopeptide which is positioned at the epsilon -amino group, or, preferably, represents hydrogen, as well as physiologically tolerable salts and therapeutically acceptable complexes thereof can be used as antidiabetics and for the treatment of gastro-intestinal bleeding in an analogous manner to somatostatin. They can be obtained by conventional processes of peptide chemistry, especially by the cyclization of corresponding linear peptides.
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Inventors:
BURUNO KANBAA
Application Number:
JP22643682A
Publication Date:
July 11, 1983
Filing Date:
December 24, 1982
Export Citation:
Assignee:
CIBA GEIGY AG
International Classes:
A61K38/00; A61K38/04; A61P5/00; C07K7/64; A61P7/04; C07K1/113; C07K14/575; C07K14/655; (IPC1-7): A61K37/02; A61K37/43; C07C103/52
Attorney, Agent or Firm:
Aoki Akira