Title:
薬剤の選択的送達のためのプロドラッグとしての環状ペルオキシド
Document Type and Number:
Japanese Patent JP6889433
Kind Code:
B2
Abstract:
Disclosed herein, inter alia, are prodrug compositions and methods of using the same for treatment and detection of disease. Specifically, disclosed herein is a compound of formula (I) having spiro-fused 1,2,4-trioxolane and piperidine rings, namely, 1,2,4-trioxa-8-azaspiro[4.5] decane. Also disclosed is a pharmaceutical composition containing the compound and a pharmaceutically acceptable carrier.
Inventors:
Renslow, Adam Earl
Lauterbasser, Erica M. Bee
Sean Dee, Fontaine
Spangler, Benjamin Bee
Wells James A
Lauterbasser, Erica M. Bee
Sean Dee, Fontaine
Spangler, Benjamin Bee
Wells James A
Application Number:
JP2016551716A
Publication Date:
June 18, 2021
Filing Date:
February 13, 2015
Export Citation:
Assignee:
The Regents of the University of California
International Classes:
C07D323/02; A61K31/352; A61K31/357; A61K31/403; A61K31/404; A61K31/4192; A61K31/427; A61K31/438; A61K31/444; A61K31/4709; A61K31/4745; A61K31/475; A61K31/5025; A61K31/665; A61K31/695; A61K31/7068; A61K31/7072; A61K31/7076; A61P31/00; A61P31/04; A61P33/00; A61P33/06; A61P35/00; A61P35/02; C07D405/12; C07D405/14; C07D407/12; C07D417/12; C07D417/14; C07D487/04; C07D491/113; C07D491/22; C07D493/18; C07D519/04; C07F7/18; C07F9/655; C07H19/073; C07H19/167; C07H19/19
Domestic Patent References:
| JP2011502131A | ||||
| JP2007511489A | ||||
| JP2004535436A |
Foreign References:
| WO2010011684A2 | ||||
| US20040186168 | ||||
| WO2009091433A2 | ||||
| US20050256185 |
Other References:
MCCONVILLE, M., et al.,Chemical Communications,2014年,Vol. 50,pp. 186-188
TANG, Y. et al.,Bioorganic & Medicinal Chemistry Letters,2007年,Vol. 17,pp. 1260-1265
PADMANILAYAM, M. et al.,Bioorganic & Medicinal Chemistry Letters,2006年,Vol. 16,pp. 5542-5545
FIGUEIREDO, A. F. et al.,Journal of Computational and Theoretical Nanoscience,2011年,Vol. 8,pp. 1847-1856
ZHAO, Q. et al.,Journal of Medicinal Chemistry,2010年,Vol. 53,pp. 4223-4233
LAURENT, S. A.-L. et al.,European Journal of Organic Chemistry,2008年,pp. 895-913
BARTON, V. et al.,Journal of Medicinal Chemistry,2010年,Vol. 53,pp. 4555-4559
ARAUJO, N. C. P. et al.,Bioorganic & Medicinal Chemistry Letters,2009年,Vol. 19,pp. 2038-2043
STOCKS, P. A. et al.,Angewandte Chemie International Edition,2007年,Vol. 46,pp. 6278-6283
HARTWIG, C. L. et al.,Journal of Medicinal Chemistry,2011年,Vol. 54,pp. 8207-8213
TANG, Y. et al.,Bioorganic & Medicinal Chemistry Letters,2007年,Vol. 17,pp. 1260-1265
PADMANILAYAM, M. et al.,Bioorganic & Medicinal Chemistry Letters,2006年,Vol. 16,pp. 5542-5545
FIGUEIREDO, A. F. et al.,Journal of Computational and Theoretical Nanoscience,2011年,Vol. 8,pp. 1847-1856
ZHAO, Q. et al.,Journal of Medicinal Chemistry,2010年,Vol. 53,pp. 4223-4233
LAURENT, S. A.-L. et al.,European Journal of Organic Chemistry,2008年,pp. 895-913
BARTON, V. et al.,Journal of Medicinal Chemistry,2010年,Vol. 53,pp. 4555-4559
ARAUJO, N. C. P. et al.,Bioorganic & Medicinal Chemistry Letters,2009年,Vol. 19,pp. 2038-2043
STOCKS, P. A. et al.,Angewandte Chemie International Edition,2007年,Vol. 46,pp. 6278-6283
HARTWIG, C. L. et al.,Journal of Medicinal Chemistry,2011年,Vol. 54,pp. 8207-8213
Attorney, Agent or Firm:
Kawaguchi International Patent Office