PURPOSE: To provide the subject compound which has the ability to inhibit angiotensinogen-cleaving action of the natural proteolytic enzyme, renin and is useful for preventing and treating renin-associated hypertension, hyperaldosteronism, congestive heart failure and glaucoma.
CONSTITUTION: The compound is expressed by formula I [A is H, Het(Het is monocyclic ring having 5-7 ring members or bicyclic ring having 7-10 ring members, which may be substituted and contains 1 or 2 nitrogen atoms), aryl, etc.; B is formulae II-IV (R3 is H, alkyl, aryl, etc.; R11 and A1 are each H or alkyl), etc., or A and B together form formula V, etc.; R1 is alkyl, aryl, cycloalkyl or saturated heterocycle having 5-6 ring members; R15 is alkyl, aryl, imidazol-4-yl, etc.; D is single bond, O, S, CO, etc.; (s) is 0-1; (t) is I-4; W is O, NR23 (R23is H or alkyl); R16 is H, alkyl, aryl, Het, etc.; Y is OCO, CH2CO, etc.; Z is NH2, OH, alkyl, etc.; R24 is H or alkyl], e.g. the compound of formula IV, and shows inhibiting action against HIV protease.
AASAA EE PACHIETSUTO
UIRIAMU JIEE GURIINRII
UIRIAMU ETSUCHI PAASONZU
TOMASU EE HARUGUREN
AN II UEEBAA
RIFU YANGU
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