PURPOSE: To provide new compounds which inhibit the angiotensinogen-cutting action of the natural proteolytic enzyme, renin.
CONSTITUTION: This compound is represented by formula I [A is H, Het (Het is 5-7 membered monocyclic ring having one or two Ns, 7-10 membered bicyclic ring), aryl or the like; B is formula II-formula IV or the like; A together with my form formula V, formula VI (R3 is H, alkyl, aryl or the like; R11 is H, alkyl; Q is CO, SO2; (r) and (m) are each 0-2) or the like; R1 is alkyl, aryl, cycloalkyl, 5-6 membered saturated heterocycle; R15 is alkyl, aryl, imidazol-4-yl, or the like; D is single bond, O, S, NH, CH=CH or the like; Z is NH2, OH, OPO3H2, alkyl or the like; W is NR23 (R23 is H, alkyl; V is formula VII (Y is O, NH, absence, or the like; (x) and (y) are each 0-1; (z) is 0-4; R5 is H, alkyl, aryl or the like; R10 is H, OH, aryl or the like), SO2NH2 or the like]. The compound is effectively used for the medical treatments of hypertension, congestive heart failure or the like relating to renin.
RARUFU EE RIBUERO
AN II UEBAA
