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Title:
モノアミン再取り込み阻害剤としてのシクロアルキルアミン
Document Type and Number:
Japanese Patent JP5432526
Kind Code:
B2
Abstract:
The invention relates to novel cyclohexylamine derivatives and their use in the treatment and/or prevention of central nervous system (CNS) disorders, such as depression, anxiety, schizophrenia and sleep disorder as well as methods for their synthesis. The invention also relates to pharmaceutical compositions containing the compounds of the invention, as well as methods of inhibiting reuptake of endogenous monoamines, such as dopamine, serotonin and norepinephrine from the synaptic cleft and methods of modulating one or more monoamine transporter.

Inventors:
Xiao, rimming
Wang, Feng Jiang
Malcolm, Scott, Christopher
Hued, michael, charles
Bush, Rally, Earl.
Ma, Giango
Bernie, Mark, A.
Campbell, Una
Angel, sharon, ray
Hardy, rally, wendel
Kosh, patrick
Campbell, John, Yi.
Application Number:
JP2008549588A
Publication Date:
March 05, 2014
Filing Date:
January 05, 2007
Export Citation:
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Assignee:
Sunovion Pharmaceuticals Inc.
International Classes:
C07C211/27; A61K31/135; A61K31/341; A61K31/357; A61K31/36; A61K31/381; A61K31/40; A61K31/426; A61K31/445; A61K31/4453; A61K31/495; A61K31/5375; A61K31/538; A61P3/04; A61P11/16; A61P13/02; A61P15/00; A61P15/02; A61P15/10; A61P15/12; A61P21/00; A61P21/02; A61P25/00; A61P25/02; A61P25/04; A61P25/06; A61P25/08; A61P25/14; A61P25/16; A61P25/18; A61P25/20; A61P25/22; A61P25/24; A61P25/28; A61P43/00; C07C47/445; C07C211/29; C07C211/30; C07C211/40; C07C215/38; C07C215/42; C07C217/52; C07C217/74; C07C225/18; C07C255/46; C07C271/16; C07C323/32; C07D207/08; C07D211/14; C07D265/14; C07D277/28; C07D295/06; C07D307/52; C07D317/58; C07D317/72; C07D319/06; C07D333/20
Domestic Patent References:
JP5500521A
JP2004509103A
Foreign References:
DE1124485A
Other References:
Mndzhoyan, A. L.; Badalyan, V. E.; Samodurova, A. G.,Studies of substituted acetic acids. XXXII. Amino esters of 1-(α-naphthyl)cycloalkane-1-carboxylic acids and 1-(α-naphthyl)cycloalkane-1-methylguanidines,Armyanskii Khimicheskii Zhurnal ,1976年,29(2),194-9
Attorney, Agent or Firm:
Toru Ishikawa



 
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