シクロアルキル、ラクタム、ラクトンおよびその関連化合物およびその医薬組成物、並びに該化合物を用いたβ-アミロイドペプチドの放出および/またはその合成を阻害する方法

Japanese Patent JP3812952

B2

Disclosed are compounds which inhibit beta -amyloid peptide release and/or its synthesis, and, accordingly, have utility in treating Alzheimer's disease. Also disclosed are pharmaceutical compositions comprising a compound which inhibits beta -amyloid peptide release and/or its synthesis as well as methods for treating Alzheimer's disease both prophylactically and therapeutically with such pharmaceutical compositions.

U, gin
Toon, Jay S
Somerset, Eugene Di
Cambers, Selena Jane
Jeffrey S. Nissen
Specialty Coating Systems, Inc.
Latimer, Lee H
John, Burgess
Friedman, Stephen
Britton, Thomas Sea
Odya, James E
Lille, John Kay
Mably, Thomas Y
Dressman, Bruce A.
Cwi, Cynthia El
Droste, James Jay
Henry S. Steven Es
Stacy Elle, McDaniel
Scott, William Leonard
Hayes, Byron Gee
Porter, warren jay

JP52886798A

August 23, 2006

December 22, 1997

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Elan Pharmaceuticals, Inc.
Eli Lilly and Company

C07D223/18; A61K31/55; C07D243/16; A61K31/551; A61K31/5513; A61K31/5517; A61P25/28; A61P43/00; C07C237/22; C07D207/273; C07D211/76; C07D223/10; C07D223/16; C07D243/12; C07D243/24; C07D243/38; C07D267/14; C07D281/10; C07D307/33; C07D309/30; C07D401/04; C07D401/14; C07D409/12; C07D409/14; C07D487/04; C07K5/087; C07K5/113; C07K14/18; A61K38/00; C07D207/26; C07C

JP5175056A
JP10101560A

WO1996025408A1
WO1998004539A1

Aoyama Aoi
Kyousei Tamura

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