CYCLOALKYL SUBSTITUTED 4-AMINOPHENYLHALO DERIVATIVE AND MANUFACTURE

Title:

CYCLOALKYL SUBSTITUTED 4-AMINOPHENYLHALO DERIVATIVE AND MANUFACTURE

Document Type and Number:

Japanese Patent JPS63192740

Kind Code:

A

Abstract:

Cycloakyl substituted 4-aminophenyl halo derivatives of formula (I) wherein n is an integer of 1 to 5; A is @C=O or -CH2- and B is, independently, -O-, -NH- or -CH2-; and either R is halogen and R1 is unsubstituted C1-C4 alkyl; or R is hydrogen and R1 is C1-C4 alkyl substituted by 1 to 4 halogen atoms; and the pharmaceutically acceptable salts thereof; show aromatase inhibiting activity and find use, for example, in the treatment of estrogen dependent tumors and of prostatic hyperplasia.

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Inventors:

ANJIERO KURUNIYOORA
ENRIKO DEI SARE
PAORO RONBARUDEI

Application Number:

JP819088A

Publication Date:

August 10, 1988

Filing Date:

January 18, 1988

Export Citation:

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Assignee:

ERBA FARMITALIA

International Classes:

A61K31/13; A61K31/135; A61K31/16; A61K31/165; A61K31/195; A61K31/205; A61K31/215; A61K31/24; A61P35/00; A61P43/00; C12N9/99; C07C67/00; C07C209/00; C07C209/36; C07C209/50; C07C209/68; C07C211/44; C07C211/45; C07C211/53; C07C213/00; C07C217/76; C07C221/00; C07C225/22; C07C227/00; C07C227/04; C07C227/18; C07C229/10; C07C229/42; C07C231/00; C07C231/02; C07C231/12; C07C233/00; C07C233/08; C07C233/12; C07C237/20; C07C237/38; C07F13/00; A61K; C07C; (IPC1-7): A61K31/135; A61K31/165; A61K31/215; C07C85/11; C07C85/24; C07C87/50; C07C93/14; C07C97/10; C07C99/00; C07C101/447; C07C103/76; C12N9/99

Attorney, Agent or Firm:

Yoshio Kawaguchi (2 outside)

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