To provide a cyclobutene derivative having an excellent ileum type bile acid transporter-inhibiting action, its pharmacologically acceptable salt, its ester or other derivatives.
The cyclobutene derivative of general formula (I) [R1 is a cycloalkyl, an aryl, a heterogeneous ring or the like; R2 is a cycloalkyl, an aryl, a heterogeneous ring or the like; R3 and R4 are each H or the like; A is formula (A-1) (R5 is H or the like; R6 is an amine residue or the like; X and Y are each oxygen atom or the like; Z is a single bond or the like); G is an alkylene or the like; when the broken line is a double bond, D is a carbon atom, and E is a group having =N-0; when the broken line is a single bond, D is a group having CH, and E is a group having NH or the like], its pharmacologically acceptable salt, its ester or other derivatives.
FURUHAMA TAKAFUMI
KOUNO KEITA
KITAYAMA TAKESHI
