Title:
シクロヘキサン誘導体化合物
Document Type and Number:
Japanese Patent JP5753179
Kind Code:
B2
Abstract:
To find a therapeutic and/or prophylactic agent for gastrointestinal disorders and so on, the agent having excellent activity and high safety. A compound represented by the following general formula (I) or a pharmacologically acceptable salt thereof. In the formula, A represents an optionally substituted phenylene group; B represents an optionally substituted 4- to 10-membered heterocyclic group, an optionally substituted C6-C10 aryl group, or an optionally substituted C3-C10 cycloalkyl group; R 1 represents a hydrogen atom or a C1-C3 alkyl group; R 2 represents a hydrogen atom or a C1-C3 alkyl group; R 3 represents a C1-C6 alkyl group, a C3-C10 cycloalkyl group, a C1-C3 alkoxy C1-C3 alkyl group, or a C1-C3 hydroxyalkyl group; R 4 represents a hydrogen atom, a C1-C6 alkyl group, or a halogen atom; n represents an integer of 1 to 4; and X represents methylene, -O-, -NH-, -N(C1-C3 alkyl)-, -C(=O)-, -S-, -S(O)-, -S(O 2 )- or a single bond.
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Inventors:
Toda Narihiro
Rieko Takano
Ken Shida
Takahiro Katagiri
Mitsuhiro Iwamoto
Shinji Akita
Mami Yamazaki
Rieko Takano
Ken Shida
Takahiro Katagiri
Mitsuhiro Iwamoto
Shinji Akita
Mami Yamazaki
Application Number:
JP2012536427A
Publication Date:
July 22, 2015
Filing Date:
September 26, 2011
Export Citation:
Assignee:
Daiichi Sankyo Co., Ltd.
International Classes:
A61K31/495; C07D213/64; A61K31/496; A61P1/00; A61P1/04; A61P1/10; A61P1/14; C07D241/04; C07D295/12; C07D401/12; C07D403/12; C07D413/12
Foreign References:
| WO2008000729A1 | 2008-01-03 | |||
| WO2007144400A1 | 2007-12-21 | |||
| WO2009068552A1 | 2009-06-04 | |||
| WO2005027637A1 | 2005-03-31 | |||
| WO2001085694A2 | 2001-11-15 | |||
| WO2008000729A1 | 2008-01-03 | |||
| WO2007144400A1 | 2007-12-21 | |||
| WO2009068552A1 | 2009-06-04 | |||
| WO2005027637A1 | 2005-03-31 | |||
| WO2001085694A2 | 2001-11-15 |
Attorney, Agent or Firm:
Kimiki Ishibashi
Noriko Kitano
Imamura Mayu
Toshiyasu Takemoto
Hironobu Kodama
Reiko Kanehara
Noriko Kitano
Imamura Mayu
Toshiyasu Takemoto
Hironobu Kodama
Reiko Kanehara